Seroatlas · Human Serome Atlas

ST18

Suppression of tumorigenicity 18 protein

Also known as: KIAA0535, NZF-3, NZF3, ST18_HUMAN, ZC2H2C3, ZC2HC10, ZNF387

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60284
Gene: ST18
Ensembl: ENSG00000147488
Chromosome: 8
Canonical length: 1047 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytokine-mediated signaling pathway; negative regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1047 residues, UniProt reviewed canonical sequence.

>O60284|ST18
     1  MDAEAEDKTL RTRSKGTEVP MDSLIQELSV AYDCSMAKKR TAEDQALGVP VNKRKSLLMK
    61  PRHYSPKADC QEDRSDRTED DGPLETHGHS TAEEIMIKPM DESLLSTAQE NSSRKEDRYS
   121  CYQELMVKSL MHLGKFEKNV SVQTVSENLN DSGIQSLKAE SDEADECFLI HSDDGRDKID
   181  DSQPPFCSSD DNESNSESAE NGWDSGSNFS EETKPPRVPK YVLTDHKKDL LEVPEIKTEG
   241  DKFIPCENRC DSETERKDPQ NALAEPLDGN AQPSFPDVEE EDSESLAVMT EEGSDLEKAK
   301  GNLSLLEQAI ALQAERGCVF HNTYKELDRF LLEHLAGERR QTKVIDMGGR QIFNNKHSPR
   361  PEKRETKCPI PGCDGTGHVT GLYPHHRSLS GCPHKVRVPL EILAMHENVL KCPTPGCTGR
   421  GHVNSNRNTH RSLSGCPIAA AEKLAMSQDK NQLDSPQTGQ CPDQAHRTSL VKQIEFNFPS
   481  QAITSPRATV SKEQEKFGKV PFDYASFDAQ VFGKRPLIQT VQGRKTPPFP ESKHFPNPVK
   541  FPNRLPSAGA HTQSPGRASS YSYGQCSEDT HIAAAAAILN LSTRCREATD ILSNKPQSLH
   601  AKGAEIEVDE NGTLDLSMKK NRILDKSAPL TSSNTSIPTP SSSPFKTSSI LVNAAFYQAL
   661  CDQEGWDTPI NYSKTHGKTE EEKEKDPVSS LENLEEKKFP GEASIPSPKP KLHARDLKKE
   721  LITCPTPGCD GSGHVTGNYA SHRSVSGCPL ADKTLKSLMA ANSQELKCPT PGCDGSGHVT
   781  GNYASHRSLS GCPRARKGGV KMTPTKEEKE DPELKCPVIG CDGQGHISGK YTSHRTASGC
   841  PLAAKRQKEN PLNGASLSWK LNKQELPHCP LPGCNGLGHV NNVFVTHRSL SGCPLNAQVI
   901  KKGKVSEELM TIKLKATGGI ESDEEIRHLD EEIKELNESN LKIEADMMKL QTQITSMESN
   961  LKTIEEENKL IEQNNESLLK ELAGLSQALI SSLADIQLPQ MGPISEQNFE AYVNTLTDMY
  1021  SNLERDYSPE CKALLESIKQ AVKGIHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ST18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 22 nTPM
cerebellum: 20 nTPM
midbrain: 13 nTPM
hippocampal formation: 10 nTPM
retina: 7.5 nTPM
basal ganglia: 7.2 nTPM

Single-cell type

oligodendrocytes: 4,251 nCPM
gonadotrophs: 862 nCPM
retinal bipolar cells: 563 nCPM
tuft cells: 415 nCPM
corticotrophs: 369 nCPM
neuroendocrine cells: 328 nCPM

Immune cell

myeloid DC: 0.2 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 167 nTPM
medulla oblongata: 102 nTPM
basal ganglia: 100 nTPM
cerebellum: 89 nTPM
pons: 86 nTPM
midbrain: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 0.25
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ST18 as an antibody target. Whether an autoantibody or antibody against ST18 could matter depends on whether native ST18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ST18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ST18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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