Seroatlas · Human Serome Atlas

SSX1

Protein SSX1

Also known as: CT5.1, SSX1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16384
Gene
SSX1
Ensembl
ENSG00000126752
Chromosome
X
Canonical length
188 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli

OverviewNCBI Gene

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX2 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

188 residues, UniProt reviewed canonical sequence.

>Q16384|SSX1
     1  MNGDDTFAKR PRDDAKASEK RSKAFDDIAT YFSKKEWKKM KYSEKISYVY MKRNYKAMTK
    61  LGFKVTLPPF MCNKQATDFQ GNDFDNDHNR RIQVEHPQMT FGRLHRIIPK IMPKKPAEDE
   121  NDSKGVSEAS GPQNDGKQLH PPGKANISEK INKRSGPKRG KHAWTHRLRE RKQLVIYEEI
   181  SDPEEDDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62
Highest tissue expression
6.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 6.9 nTPM
  • epididymis: 0.3 nTPM
  • thyroid gland: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • fallopian tube: 0.1 nTPM
  • parathyroid gland: 0.1 nTPM

Single-cell type

  • early primary spermatocytes: 38 nCPM
  • differentiating spermatogonia: 21 nCPM
  • undifferentiated spermatogonia: 5.1 nCPM
  • late spermatids: 1.5 nCPM
  • mast cells: 0.3 nCPM
  • melanocytes: 0.2 nCPM

Immune cell

  • basophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 1.3 nTPM
  • white matter: 0.8 nTPM
  • basal ganglia: 0.7 nTPM
  • cerebral cortex: 0.7 nTPM
  • midbrain: 0.7 nTPM
  • pons: 0.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SSX1.

Disease | AllUniProt

Conditions SSX1 is implicated in, by any mechanism.

  • Spermatogenic failure, X-linked, 5 (SPGFX5) MIM:301099

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on SSX1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
2
gnomAD pLI
0
gnomAD missense Z
-4.37
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSX1 as an antibody target. Whether an autoantibody or antibody against SSX1 could matter depends on whether native SSX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy.

Canonical record: https://seroatlas.com/gene/SSX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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