Seroatlas · Human Serome Atlas

SSUH2

Protein SSUH2 homolog

Also known as: C3orf32, fls485, ssu-2, SSUH2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2M2
Gene: SSUH2
Ensembl: ENSG00000125046
Chromosome: 3
Canonical length: 375 aa
Protein class: Disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable heat shock protein binding activity and unfolded protein binding activity. Involved in odontogenesis. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

375 residues, UniProt reviewed canonical sequence.

>Q9Y2M2|SSUH2
     1  MDRDLNEDDS VVDLSFEAES PLAPPTELLE RLPSYDWLLQ GGRGQIFFPP LEAPGRPQEQ
    61  RSWPSFLEHR VPAMTEEVAR EALLSFVDSK CCYSSTVAGD LVIQELKRQT LCRYRLETFS
   121  ESRISEWTFQ PFTNHSVDGP QRGASPRLWD IKVQGPPMFQ EDTRKFQVPH SSLVKECHKC
   181  HGRGRYKCSG CHGAGTVRCP SCCGAKRKAK QSRRCQLCAG SGRRRCSTCS GRGNKTCATC
   241  KGEKKLLHFI QLVIMWKNSL FEFVSEHRLN CPRELLAKAK GENLFKDENS VVYPIVDFPL
   301  RDISLASQRG IAEHSAALAS RARVLQQRQT IELIPLTEVH YWYQGKTYVY YIYGTDHQVY
   361  AVDYPERYCC GCTIV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSUH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 6.2 nTPM

Expression across tissuesHPA

Tissue

duodenum: 6.2 nTPM
small intestine: 6.2 nTPM
testis: 5.2 nTPM
heart muscle: 2.5 nTPM
breast: 1.7 nTPM
spleen: 1.5 nTPM

Single-cell type

early spermatids: 141 nCPM
cardiomyocytes: 126 nCPM
late spermatids: 114 nCPM
late primary spermatocytes: 51 nCPM
myonuclei: 30 nCPM
enterocytes: 21 nCPM

Immune cell

memory CD8 T-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
gdT-cell: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
naive B-cell: 0.2 nTPM

Brain region

midbrain: 1.9 nTPM
basal ganglia: 1.7 nTPM
medulla oblongata: 1.6 nTPM
pons: 1.6 nTPM
white matter: 1.6 nTPM
cerebral cortex: 1.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SSUH2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 77 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

DENTIN DYSPLASIA, TYPE IC

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: 0.24
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

odontogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Heat shock protein DnaJ, cysteine-rich domain
Protein SSUH2 homolog

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSUH2 as an antibody target. Whether an autoantibody or antibody against SSUH2 could matter depends on whether native SSUH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSUH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSUH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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