Seroatlas · Human Serome Atlas

SSU72L1

RNA polymerase II subunit A C-terminal domain phosphatase SSU72 like protein 1

Also known as: S72L1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1W2PQ27
Gene: SSU72L1
Canonical length: 194 aa

OverviewNCBI Gene

No narrative summary is available for SSU72L1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>A0A1W2PQ27|SSU72L1
     1  MLSSTLRVAV VCVSNVNRSM EAHSILRRKG LSVRSFGTES HVRLPGPRPN RPVVYDFATT
    61  YKEMYNDLLR KDRERYTRNG ILHILGRNER IKPGPERFQE CTDFFDVIFT CEESVYDTVV
   121  EDLCSREQQT FQPVHVINME IQDTLEDATL GAFLICEICQ CLQQSDDMED NLEELLLQME
   181  EKAGKSFLHT VCFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSU72L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27

OntologyGO

Biological processes

Molecular functions

RNA polymerase II CTD heptapeptide repeat phosphatase activity

Cellular components

mRNA cleavage and polyadenylation specificity factor complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSU72L1 as an antibody target. Whether an autoantibody or antibody against SSU72L1 could matter depends on whether native SSU72L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSU72L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSU72L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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