SSPN
Sarcospan
Also known as: KRAG, SPN1, SPN2, SSPN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q14714
- Gene
- SSPN
- Ensembl
- ENSG00000123096
- Chromosome
- 12
- Canonical length
- 243 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Nuclear membrane
OverviewNCBI Gene
This gene encodes a member of the dystrophin-glycoprotein complex (DGC). The DGC spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Two alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]
Canonical amino-acid sequenceUniProt
243 residues, UniProt reviewed canonical sequence.
>Q14714|SSPN
1 MGKNKQPRGQ QRQGGPPAAD AAGPDDMEPK KGTGAPKECG EEEPRTCCGC RFPLLLALLQ
61 LALGIAVTVV GFLMASISSS LLVRDTPFWA GIIVCLVAYL GLFMLCVSYQ VDERTCIQFS
121 MKLLYFLLSA LGLTVCVLAV AFAAHHYSQL TQFTCETTLD SCQCKLPSSE PLSRTFVYRD
181 VTDCTSVTGT FKLFLLIQMI LNLVCGLVCL LACFVMWKHR YQVFYVGVRI CSLTASEGPQ
241 QKILocalizationUniProt · AlphaFold · HPA
Whether an antibody against SSPN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 4
- Mean surface accessibility (rSASA)
- 0.42
- Highest tissue expression
- 74 nTPM
Expression across tissuesHPA
Tissue
- tongue: 74 nTPM
- skeletal muscle: 57 nTPM
- heart muscle: 43 nTPM
- cervix: 37 nTPM
- ovary: 33 nTPM
- seminal vesicle: 32 nTPM
Single-cell type
- thymic myoid cells: 296 nCPM
- peritubular myoid cells: 249 nCPM
- breast myoepithelial cells: 196 nCPM
- smooth muscle cells: 165 nCPM
- epicardial cells: 164 nCPM
- b-cells: 152 nCPM
Immune cell
- memory B-cell: 58 nTPM
- naive B-cell: 17 nTPM
- neutrophil: 3 nTPM
- eosinophil: 2.7 nTPM
- total PBMC: 0.7 nTPM
- MAIT T-cell: 0.5 nTPM
Brain region
- white matter: 77 nTPM
- spinal cord: 65 nTPM
- hypothalamus: 63 nTPM
- midbrain: 60 nTPM
- medulla oblongata: 58 nTPM
- cerebellum: 53 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.17
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 0.97
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SSPN as an antibody target. Whether an autoantibody or antibody against SSPN could matter depends on whether native SSPN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SSPN is annotated at the cell surface, where native SSPN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SSPN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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