Seroatlas · Human Serome Atlas

SSMEM1

Serine-rich single-pass membrane protein 1

Also known as: C7orf45, FLJ40316, SSMM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WWF3
Gene: SSMEM1
Ensembl: ENSG00000165120
Chromosome: 7
Canonical length: 244 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q8WWF3|SSMEM1
     1  MGDLFSLFWE VDPPPIPVNC AIPNQDYECW KDDSCGTIGS FLLWYFVIVF VLMFFSRASV
    61  WMSEDKKDEG SGTSTSVRKA SKETSCKRQS KDSAWDPSQT MKKPKQNQLT PVTNSEVALV
   121  NAYPEQRRAR RQSQFNEVNQ NQHDSDTTEY GSEESNSEAS SWKESESEHH PSPDSIKRRK
   181  MAQRQRNLGS YQMSERHCLH CKALRTNEWL AHHSRQKPSV TPPMKRDSQE ESSISDINKK
   241  FSKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSMEM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
choroid plexus: 0.1 nTPM
lung: 0.1 nTPM
pancreas: 0.1 nTPM
placenta: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

early spermatids: 472 nCPM
late primary spermatocytes: 453 nCPM
late spermatids: 46 nCPM
early primary spermatocytes: 8.2 nCPM
undifferentiated spermatogonia: 2.3 nCPM
sertoli cells: 2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
white matter: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.94
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

Protein of unknown function DUF4636
Domain of unknown function (DUF4636)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSMEM1 as an antibody target. Whether an autoantibody or antibody against SSMEM1 could matter depends on whether native SSMEM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSMEM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSMEM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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