Seroatlas · Human Serome Atlas

SSH3

Protein phosphatase Slingshot homolog 3

Also known as: FLJ10928, FLJ20515, SSH3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TE77
Gene: SSH3
Ensembl: ENSG00000172830
Chromosome: 11
Canonical length: 659 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane,Actin filaments,Cytosol

OverviewNCBI Gene

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

659 residues, UniProt reviewed canonical sequence.

>Q8TE77|SSH3
     1  MALVTVSRSP PGSGASTPVG PWDQAVQRRS RLQRRQSFAV LRGAVLGLQD GGDNDDAAEA
    61  SSEPTEKAPS EEELHGDQTD FGQGSQSPQK QEEQRQHLHL MVQLLRPQDD IRLAAQLEAP
   121  RPPRLRYLLV VSTREGEGLS QDETVLLGVD FPDSSSPSCT LGLVLPLWSD TQVYLDGDGG
   181  FSVTSGGQSR IFKPISIQTM WATLQVLHQA CEAALGSGLV PGGSALTWAS HYQERLNSEQ
   241  SCLNEWTAMA DLESLRPPSA EPGGSSEQEQ MEQAIRAELW KVLDVSDLES VTSKEIRQAL
   301  ELRLGLPLQQ YRDFIDNQML LLVAQRDRAS RIFPHLYLGS EWNAANLEEL QRNRVTHILN
   361  MAREIDNFYP ERFTYHNVRL WDEESAQLLP HWKETHRFIE AARAQGTHVL VHCKMGVSRS
   421  AATVLAYAMK QYECSLEQAL RHVQELRPIA RPNPGFLRQL QIYQGILTAS RQSHVWEQKV
   481  GGVSPEEHPA PEVSTPFPPL PPEPEGGGEE KVVGMEESQA APKEEPGPRP RINLRGVMRS
   541  ISLLEPSLEL ESTSETSDMP EVFSSHESSH EEPLQPFPQL ARTKGGQQVD RGPQPALKSR
   601  QSVVTLQGSA VVANRTQAFQ EQEQGQGQGQ GEPCISSTPR FRKVVRQASV HDSGEEGEA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSH3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

esophagus: 43 nTPM
urinary bladder: 41 nTPM
vagina: 33 nTPM
prostate: 31 nTPM
cervix: 30 nTPM
cerebellum: 27 nTPM

Single-cell type

breast lactating cells: 97 nCPM
esophageal apical cells: 84 nCPM
prostatic hillock cells: 76 nCPM
urothelial cells: 75 nCPM
esophageal suprabasal cells: 59 nCPM
prostatic club cells: 58 nCPM

Immune cell

basophil: 12 nTPM
eosinophil: 11 nTPM
neutrophil: 4.4 nTPM
intermediate monocyte: 2.3 nTPM
gdT-cell: 2 nTPM
memory CD4 T-cell: 1.9 nTPM

Brain region

medulla oblongata: 24 nTPM
white matter: 24 nTPM
cerebellum: 22 nTPM
pons: 20 nTPM
spinal cord: 19 nTPM
basal ganglia: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.6
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSH3 as an antibody target. Whether an autoantibody or antibody against SSH3 could matter depends on whether native SSH3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSH3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSH3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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