Seroatlas · Human Serome Atlas

SSC4D

Scavenger receptor cysteine-rich domain-containing group B protein

Also known as: S4D-SRCRB, SRB4D_HUMAN, SRCRB-S4D, SRCRB4D

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WTU2
Gene: SSC4D
Ensembl: ENSG00000146700
Chromosome: 7
Canonical length: 575 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

The scavenger receptor cysteine-rich (SRCR) superfamily is an ancient and highly conserved group of cell surface and/or secreted proteins, some of which are involved in the development of the immune system and the regulation of both innate and adaptive immune responses. Group B SRCR domains usually contain 8 regularly spaced cysteines that give rise to a well-defined intradomain disulfide-bond pattern.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

575 residues, UniProt reviewed canonical sequence.

>Q8WTU2|SSC4D
     1  MHKEAEMLIG PQLDEKRWGW RLGDGSAAPP FLPQALSFLL LLPLASALQP TPLPFQELRL
    61  VGGPSRCRGR LEVMHGGSWG SVCDDDWDVV DANVVCRQLG CGLALPVPRP LAFGQGRGPI
   121  LLDNVECRGQ EAALSECGSR GWGVHNCFHY EDVAVLCDEF LPTQPPTRKM LTSRAPPTTL
   181  PNGKSEGSVR LVGGANLCQG RVEILHSGLW GTVCDDDWGL PDAAVVCRQL GCGAAMAATT
   241  NAFFGYGTGH ILLDNVHCEG GEPRLAACQS LGWGVHNCGH HEDAGALCAG LGPPTLTALP
   301  SSATREDWAW QTDPSATGVG PQPSRETALL TTAAWAAGKK SGRLRLVGGP GPCRGRVEVL
   361  HAGGWGTVCD DDWDFADARV ACREAGCGPA LGATGLGHFG YGRGPVLLDN VGCAGTEARL
   421  SDCFHLGWGQ HNCGHHEDAG ALCAGPEELG LQVQQDGSET TRVPTPRPRD GHLRLVNGAH
   481  RCEGRVELYL GQRWGTVCDD AWDLRAAGVL CRQLGCGQAL AAPGEAHFGP GRGPILLDNV
   541  KCRGEESALL LCSHIRWDAH NCDHSEDASV LCQPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSC4D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 6.6 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 6.6 nTPM
kidney: 2.5 nTPM
pituitary gland: 2.4 nTPM
pancreas: 2 nTPM
thyroid gland: 2 nTPM
salivary gland: 0.9 nTPM

Single-cell type

renal connecting tubule cells: 40 nCPM
distal convoluted tubule cells: 39 nCPM
gonadotrophs: 35 nCPM
renal collecting duct principal cells: 24 nCPM
loop of henle epithelial cells: 21 nCPM
retinal ganglion cells: 19 nCPM

Immune cell

classical monocyte: 0.1 nTPM
intermediate monocyte: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 3 nTPM
basal ganglia: 2 nTPM
pons: 1.9 nTPM
amygdala: 1.7 nTPM
cerebral cortex: 1.7 nTPM
hippocampal formation: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSC4D as an antibody target. Whether an autoantibody or antibody against SSC4D could matter depends on whether native SSC4D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSC4D is annotated as secreted, so native SSC4D circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SSC4D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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