Seroatlas · Human Serome Atlas

SSBP3

Single-stranded DNA-binding protein 3

Also known as: CSDP, FLJ10355, SSBP3_HUMAN, SSDP, SSDP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BWW4
Gene
SSBP3
Ensembl
ENSG00000157216
Chromosome
1
Canonical length
388 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Predicted to enable single-stranded DNA binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>Q9BWW4|SSBP3
     1  MFAKGKGSAV PSDGQAREKL ALYVYEYLLH VGAQKSAQTF LSEIRWEKNI TLGEPPGFLH
    61  SWWCVFWDLY CAAPERRDTC EHSSEAKAFH DYSAAAAPSP VLGNIPPNDG MPGGPIPPGF
   121  FQGPPGSQPS PHAQPPPHNP SSMMGPHSQP FMSPRYAGGP RPPIRMGNQP PGGVPGTQPL
   181  LPNSMDPTRQ QGHPNMGGSM QRMNPPRGMG PMGPGPQNYG SGMRPPPNSL GPAMPGINMG
   241  PGAGRPWPNP NSANSIPYSS SSPGTYVGPP GGGGPPGTPI MPSPADSTNS SDNIYTMINP
   301  VPPGGSRSNF PMGPGSDGPM GGMGGMEPHH MNGSLGSGDI DGLPKNSPNN ISGISNPPGT
   361  PRDDGELGGN FLHSFQNDNY SPSMTMSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SSBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
98 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 98 nTPM
  • ovary: 94 nTPM
  • cerebral cortex: 90 nTPM
  • cerebellum: 73 nTPM
  • thymus: 63 nTPM
  • endometrium: 58 nTPM

Single-cell type

  • erythrocyte progenitors: 352 nCPM
  • ependymal cells: 300 nCPM
  • podocytes: 299 nCPM
  • sertoli cells: 295 nCPM
  • vascular smooth muscle cells: 264 nCPM
  • distal convoluted tubule cells: 239 nCPM

Immune cell

  • naive CD4 T-cell: 5.8 nTPM
  • naive CD8 T-cell: 5.8 nTPM
  • gdT-cell: 5.6 nTPM
  • memory CD8 T-cell: 4.9 nTPM
  • memory CD4 T-cell: 4.4 nTPM
  • MAIT T-cell: 3.5 nTPM

Brain region

  • cerebral cortex: 170 nTPM
  • basal ganglia: 116 nTPM
  • white matter: 110 nTPM
  • cerebellum: 89 nTPM
  • hypothalamus: 72 nTPM
  • hippocampal formation: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.2
gnomAD pLI
1
gnomAD missense Z
2.75
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SSBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SSBP3 as an antibody target. Whether an autoantibody or antibody against SSBP3 could matter depends on whether native SSBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SSBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SSBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SSBP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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