SRXN1
Sulfiredoxin-1
Also known as: C20orf139, dJ850E9.2, Npn3, SRX1, SRXN1_HUMAN, YKL086W
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BYN0
- Gene
- SRXN1
- Ensembl
- ENSG00000271303
- Chromosome
- 20
- Canonical length
- 137 aa
- Protein class
- Enzymes, Predicted intracellular proteins
OverviewNCBI Gene
Enables oxidoreductase activity, acting on a sulfur group of donors. Involved in response to oxidative stress. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
137 residues, UniProt reviewed canonical sequence.
>Q9BYN0|SRXN1
1 MGLRAGGTLG RAGAGRGAPE GPGPSGGAQG GSIHSGRIAA VHNVPLSVLI RPLPSVLDPA
61 KVQSLVDTIR EDPDSVPPID VLWIKGAQGG DYFYSFGGCH RYAAYQQLQR ETIPAKLVQS
121 TLSDLRVYLG ASTPDLQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SRXN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 65 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 65 nTPM
- adrenal gland: 63 nTPM
- skeletal muscle: 46 nTPM
- heart muscle: 37 nTPM
- liver: 37 nTPM
- stomach: 32 nTPM
Single-cell type
- foveolar cells: 7.5 nCPM
- other brain neurons: 7.2 nCPM
- megakaryocytes: 6.2 nCPM
- brain inhibitory neurons: 6 nCPM
- brain excitatory neurons: 5 nCPM
- neutrophils: 3.5 nCPM
Immune cell
- neutrophil: 12 nTPM
- eosinophil: 3 nTPM
- memory CD8 T-cell: 2.5 nTPM
- basophil: 2.4 nTPM
- non-classical monocyte: 2.2 nTPM
- classical monocyte: 2 nTPM
Brain region
- hypothalamus: 39 nTPM
- thalamus: 36 nTPM
- midbrain: 35 nTPM
- pons: 32 nTPM
- medulla oblongata: 32 nTPM
- cerebral cortex: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.49
- gnomAD pLI
- 0.07
- gnomAD missense Z
- 0.3
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- ParB-like, N-terminal domain
- Sulfiredoxin
- ParB/Sulfiredoxin superfamily
- ParB N-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SRXN1 as an antibody target. Whether an autoantibody or antibody against SRXN1 could matter depends on whether native SRXN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SRXN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SRXN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...