Seroatlas · Human Serome Atlas

SRRM5

Serine/arginine repetitive matrix protein 5

Also known as: SRRM5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: B3KS81
Gene: SRRM5
Ensembl: ENSG00000226763
Chromosome: 19
Canonical length: 715 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Centrosome

OverviewNCBI Gene

No narrative summary is available for SRRM5 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

715 residues, UniProt reviewed canonical sequence.

>B3KS81|SRRM5
     1  MSSPKRSSKP SMSLAPSGSS MPTADPKPPA SLKSTKSATP NRSLVPTKPA TSRNSVMSPS
    61  SSKSTKSTST KRAPSNRPSS RSRVRSKART PSRVSTDTRT SKASKASDVR CHQRRGTHSR
   121  GRTPGRRGSR SSKRSPSRAS TPGRIRTHGA RPGMASRVRT PTSQQKGSRG KSYGRPRTSN
   181  RERSDSQPRN LSKKSYRPPG GSGIGRSSEL AVTPSTAKCQ TPTGIPSKEK SDNPSPSSSR
   241  KVKSYGQMII PSREKSYSPT EMSSRVKSYN QASTRSRPQS HSQSRSPRRS RSGSQKRTHS
   301  RVRSHSWKRN HSRARSRTRK GILSQMGRHS QSRSHSKGKS QNQSRTPRRG RSHNWSRNPS
   361  KERSHSHSRS SSKERDHRGS SSPRKESGRS QSGSPNKQRD HSRSRSPNKA RDRSRSRSPY
   421  KARDRSRSRS PNKARDCSRS RSPYKARDRS RSRSPNKARD HSRSRSPNKA RDRSRSRSPS
   481  KERDHSQLGS PSKERDHRRS RSPSKERQCR QSRSSSKERD HRRSRSPSKE RQRRQSRSPN
   541  KERDRSQSRS PSEEREHRQS RSPSKERDRR RWRSPSKERE RRQSRSSSEE RDHSRSRSPN
   601  KQSGYSRPRA SSKEKAHSRS RTPSKEGNHS QSRTSSKESD PSQSTVPRSP DWKRSPTRTS
   661  SLSQNRTPSK TSSHSPSTFP SGGQTLSQDD SQADATTSKA TLPGERSSSS SSKLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRRM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.71
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

testis: 45 nTPM
cerebellum: 2.6 nTPM
prostate: 1.8 nTPM
retina: 1.7 nTPM
pituitary gland: 1.5 nTPM
kidney: 1.3 nTPM

Single-cell type

early spermatids: 245 nCPM
cardiomyocytes: 111 nCPM
late spermatids: 84 nCPM
epicardial cells: 39 nCPM
adipocytes: 22 nCPM
thymocytes: 12 nCPM

Immune cell

gdT-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 5.4 nTPM
cerebral cortex: 3.4 nTPM
basal ganglia: 2.9 nTPM
white matter: 2.9 nTPM
medulla oblongata: 2.8 nTPM
pons: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 1.15
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRRM5 as an antibody target. Whether an autoantibody or antibody against SRRM5 could matter depends on whether native SRRM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRRM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRRM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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