Seroatlas · Human Serome Atlas

SRRM3

Serine/arginine repetitive matrix protein 3

Also known as: SRRM3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NNA2
Gene: SRRM3
Canonical length: 597 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SRRM3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

597 residues, UniProt reviewed canonical sequence.

>A6NNA2|SRRM3
     1  MSSTVNNGAA SMQSTPDAAN GFPQPSSSSG TWPRAEEELR AAEPGLVKRA HREILDHERK
    61  RRVELKCMEL QEMMEEQGYS EEEIRQKVGT FRQMLMEKEG VLTREDRPGG HIVAETPRLT
   121  EGAEPGLEYA PFDDDDGPVD CDCPASCYRG HRGYRTKHWS SSSASPPPKK KKKKKGGHRR
   181  SRKKRRLESE CSCGSSSPLR KKKKSVKKHR RDRSDSGSRR KRRHRSRSSK CKRKEKNKEK
   241  KRPHTESPGR RSHRHSSGSS HSPSLSSHYS DSRSPSRLSP KHRDEGRKTG SQRSSGSRSP
   301  SPSGGSGWGS PQRNGGSGQR SGAHGGRPGS AHSPPDKPSS PSPRVRDKAA AAAPTPPARG
   361  KESPSPRSAP SSQGRGGRAA GGAGRRRRRR RRRRRSRSSA SAPRRRGRRR PRPAPPRGSS
   421  RSLSRARSSS DSGSGRGAPG PGPEPGSERG HGGHGKRAKE RPPRARPAST SPSPGAHGRR
   481  GGPEGKSSSR SPGPHPRSWS SSRSPSKSRS RSAEKRPHSP SRSPSPKKPL SRDKDGEGRA
   541  RHSEAEATRA RRRSRSYSPI RKRRRDSPSF MEPRRITSAA SVLFHTTGPA PLPPPAA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRRM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 78 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 78 nTPM
retina: 25 nTPM
basal ganglia: 14 nTPM
cerebral cortex: 11 nTPM
hypothalamus: 9.2 nTPM
pituitary gland: 8 nTPM

Single-cell type

cone photoreceptor cells: 513 nCPM
rod photoreceptor cells: 481 nCPM
retinal ganglion cells: 421 nCPM
retinal amacrine cells: 403 nCPM
retinal horizontal cells: 357 nCPM
brain inhibitory neurons: 295 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 170 nTPM
pons: 141 nTPM
cerebral cortex: 118 nTPM
medulla oblongata: 95 nTPM
basal ganglia: 81 nTPM
white matter: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0.21
gnomAD missense Z: 1.24

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

mRNA binding

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

mRNA splicing factor Cwf21 domain
Serine/arginine repetitive matrix protein, C-terminal
Serine/Arginine Repetitive Matrix Domain-Containing Protein
cwf21 domain
Serine/arginine repetitive matrix protein C-terminus
Serine/arginine repetitive matrix protein 3, cwf21 domain

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRRM3 as an antibody target. Whether an autoantibody or antibody against SRRM3 could matter depends on whether native SRRM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRRM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRRM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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