Seroatlas · Human Serome Atlas

SRRD

SRR1-like protein

Also known as: HC/HCC, SRR1L, SRR1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UH36
Gene: SRRD
Ensembl: ENSG00000100104
Chromosome: 22
Canonical length: 339 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to be involved in regulation of circadian rhythm and regulation of heme biosynthetic process. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

339 residues, UniProt reviewed canonical sequence.

>Q9UH36|SRRD
     1  MAAAAAAALE SWQAAAPRKR RSAARRPRRR EAAPRGREAA PRGREAAPRG PEAEFESDSG
    61  VVLRRIWEAE KDLFISDFWS SALETINRCL TKHLEQLKAP VGTLSDIFGN LHLDSLPEES
   121  DVATDSIPRE ILVTGTCHLK CVCYGIGNFA TCIVARNQLT FLLLLLEKCQ IPRSHCWVYD
   181  PLFSQLEIEV LNTLGVTVLS ENEEGKRSIR GEPTIFYMLH CGTALYNNLL WSNWSVDALS
   241  KMVIIGNSFK GLEERLLARI LQKNYPYIAK ILKGLEELEF PQTSQYMDIF NDTSVHWFPV
   301  QKLEQLSIDI WEFREEPDYQ DCEDLEIIRN KREDPSATD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRRD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 18 nTPM
tongue: 16 nTPM
thyroid gland: 9.8 nTPM
cerebellum: 8.5 nTPM
heart muscle: 7.1 nTPM
ovary: 7.1 nTPM

Single-cell type

late spermatids: 84 nCPM
pancreatic acinar cells: 43 nCPM
erythrocyte progenitors: 36 nCPM
erythrocytes: 33 nCPM
suprabasal keratinocytes: 30 nCPM
late primary spermatocytes: 29 nCPM

Immune cell

naive CD8 T-cell: 1.2 nTPM
memory B-cell: 1.1 nTPM
naive CD4 T-cell: 1.1 nTPM
MAIT T-cell: 1 nTPM
memory CD8 T-cell: 1 nTPM
NK-cell: 0.9 nTPM

Brain region

cerebellum: 15 nTPM
basal ganglia: 12 nTPM
cerebral cortex: 11 nTPM
hypothalamus: 11 nTPM
thalamus: 11 nTPM
amygdala: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: -0.45
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

SRR1-like domain
SRR1-like protein
SRR1 domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRRD as an antibody target. Whether an autoantibody or antibody against SRRD could matter depends on whether native SRRD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRRD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRRD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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