Seroatlas · Human Serome Atlas

SRARP

Steroid receptor-associated and regulated protein

Also known as: C1orf64, ERRF, MGC24047, SRARP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEQ6
Gene: SRARP
Ensembl: ENSG00000183888
Chromosome: 1
Canonical length: 169 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables nuclear estrogen receptor binding activity. Involved in positive regulation of intracellular estrogen receptor signaling pathway. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

169 residues, UniProt reviewed canonical sequence.

>Q8NEQ6|SRARP
     1  MAPSEDPRDW RANLKGTIRE TGLETSSGGK LAGHQKTVPT AHLTFVIDCT HGKQLSLAAT
    61  ASPPQAPSPN RGLVTPPMKT YIVFCGENWP HLTRVTPMGG GCLAQARATL PLCRGSVASA
   121  SFPVSPLCPQ EVPEAKGKPV KAAPVRSSTW GTVKDSLKAL SSCVCGQAD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRARP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 6.9 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 6.9 nTPM
midbrain: 6 nTPM
hippocampal formation: 5.1 nTPM
breast: 4.8 nTPM
spinal cord: 4.7 nTPM
hypothalamus: 4 nTPM

Single-cell type

epididymal clear cells: 92 nCPM
conjunctival goblet cells: 74 nCPM
respiratory ionocytes: 64 nCPM
breast hormone-responsive cells: 47 nCPM
salivary duct cells: 25 nCPM
salivary ionocytes: 12 nCPM

Immune cell

neutrophil: 1.6 nTPM
basophil: 0.7 nTPM
NK-cell: 0.2 nTPM
eosinophil: 0.1 nTPM
gdT-cell: 0.1 nTPM
MAIT T-cell: 0.1 nTPM

Brain region

thalamus: 13 nTPM
amygdala: 11 nTPM
pons: 11 nTPM
basal ganglia: 9.6 nTPM
medulla oblongata: 9.4 nTPM
midbrain: 9.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0.11
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

positive regulation of intracellular estrogen receptor signaling pathway

Molecular functions

nuclear estrogen receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Steroid receptor-associated and regulated protein
Steroid receptor-associated and regulated protein

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRARP as an antibody target. Whether an autoantibody or antibody against SRARP could matter depends on whether native SRARP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRARP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRARP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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