SQLE

Protein identityUniProt · HPA

UniProt accession

Q14534

Gene

SQLE

Ensembl

ENSG00000104549

Chromosome

8

Canonical length

574 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Vesicles,Cytosol

OverviewNCBI Gene

Enables FAD binding activity and squalene monooxygenase activity. Involved in lipid droplet formation; regulation of cell population proliferation; and sterol biosynthetic process. Located in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>Q14534|SQLE
     1  MWTFLGIATF TYFYKKFGDF ITLANREVLL CVLVFLSLGL VLSYRCRHRN GGLLGRQQSG
    61  SQFALFSDIL SGLPFIGFFW AKSPPESENK EQLEARRRRK GTNISETSLI GTAACTSTSS
   121  QNDPEVIIVG AGVLGSALAA VLSRDGRKVT VIERDLKEPD RIVGEFLQPG GYHVLKDLGL
   181  GDTVEGLDAQ VVNGYMIHDQ ESKSEVQIPY PLSENNQVQS GRAFHHGRFI MSLRKAAMAE
   241  PNAKFIEGVV LQLLEEDDVV MGVQYKDKET GDIKELHAPL TVVADGLFSK FRKSLVSNKV
   301  SVSSHFVGFL MKNAPQFKAN HAELILANPS PVLIYQISSS ETRVLVDIRG EMPRNLREYM
   361  VEKIYPQIPD HLKEPFLEAT DNSHLRSMPA SFLPPSSVKK RGVLLLGDAY NMRHPLTGGG
   421  MTVAFKDIKL WRKLLKGIPD LYDDAAIFEA KKSFYWARKT SHSFVVNILA QALYELFSAT
   481  DDSLHQLRKA CFLYFKLGGE CVAGPVGLLS VLSPNPLVLI GHFFAVAIYA VYFCFKSEPW
   541  ITKPRALLSS GAVLYKACSV IFPLIYSEMK YMVH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SQLE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

76 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SQLE.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 75 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hypercholesterolemia, familial, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.31

gnomAD pLI

0.98

gnomAD missense Z

1.14

DepMap mean gene effect

-0.13

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cholesterol biosynthetic process
• lipid droplet formation
• regulation of cell population proliferation
• response to biphenyl
• sterol biosynthetic process

Molecular functions

• FAD binding
• squalene monooxygenase activity

Cellular components

• endoplasmic reticulum
• endoplasmic reticulum membrane
• intracellular membrane-bounded organelle
• membrane

Protein domainsUniProt · Pfam · InterPro

• FAD/NAD(P)-binding domain superfamily
• NAD(P)-binding Rossmann-like domain
• Squalene epoxidase
• Squalene monooxygenase
• Squalene epoxidase

KeywordsUniProt

• Endoplasmic reticulum
• FAD
• Flavoprotein
• Lipid metabolism
• Membrane
• Microsome
• Oxidoreductase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of SQLE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• SMIM22
• MARCHF6