SPTY2D1

Protein identityUniProt · HPA

UniProt accession

Q68D10

Gene

SPTY2D1

Ensembl

ENSG00000179119

Chromosome

11

Canonical length

685 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli

OverviewNCBI Gene

Enables DNA binding activity; histone binding activity; and histone chaperone activity. Involved in heterochromatin formation; nucleosome assembly; and regulation of DNA-templated transcription. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

685 residues, UniProt reviewed canonical sequence.

>Q68D10|SPTY2D1
     1  MDFREILMIA SKGQGVNNVP KRYSLAVGPP KKDPKVKGVQ SAAVQAFLKR KEEELRRKAL
    61  EEKRRKEELV KKRIELKHDK KARAMAKRTK DNFHGYNGIP IEEKSKKRQA TESHTSQGTD
   121  REYEMEEENE FLEYNHAESE QEYEEEQEPP KVESKPKVPL KSAPPPMNFT DLLRLAEKKQ
   181  FEPVEIKVVK KSEERPMTAE ELREREFLER KHRRKKLETD GKLPPTVSKK APSQKESVGT
   241  KLSKGSGDRH PSSKGMPLPH AEKKSRPSMA NEKHLALSSS KSMPGERIKA GSGNSSQPSL
   301  REGHDKPVFN GAGKPHSSTS SPSVPKTSAS RTQKSAVEHK AKKSLSHPSH SRPGPMVTPH
   361  NKAKSPGVRQ PGSSSSSAPG QPSTGVARPT VSSGPVPRRQ NGSSSSGPER SISGSKKPTN
   421  DSNPSRRTVS GTCGPGQPAS SSGGPGRPIS GSVSSARPLG SSRGPGRPVS SPHELRRPVS
   481  GLGPPGRSVS GPGRSISGSI PAGRTVSNSV PGRPVSSLGP GQTVSSSGPT IKPKCTVVSE
   541  TISSKNIISR SSNGQMNGMK PPLSGYRAAQ GPQRLPFPTG YKRQREYEEE DDDDDEYDSE
   601  MEDFIEDEGE PQEEISKHIR EIFGYDRKKY KDESDYALRY MESSWKEQQK EEAKSLRLGM
   661  QEDLEEMRRE EEEMQRRRAK KLKRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPTY2D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.67

Highest tissue expression

32 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPTY2D1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 107 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Hypercholesterolemia, familial, 1

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.94

gnomAD missense Z

1.02

DepMap mean gene effect

0.06

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• heterochromatin formation
• nucleosome assembly
• regulation of DNA-templated transcription
• transcription by RNA polymerase I

Molecular functions

• DNA binding
• histone binding
• histone chaperone activity
• RNA polymerase I core binding

Cellular components

• nucleolus
• nucleoplasm

Protein domainsUniProt · Pfam · InterPro

• Chromatin SPT2
• SPT2 homolog, N-terminal
• SPT2 chromatin protein
• SPT2 N-terminal domain

KeywordsUniProt

• Acetylation
• Coiled coil
• DNA-binding
• Isopeptide bond
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of SPTY2D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• H4