Seroatlas · Human Serome Atlas

SPTSSB

Serine palmitoyltransferase small subunit B

Also known as: ADMP, C3orf57, SPTSB_HUMAN, ssSPTb

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NFR3
Gene: SPTSSB
Ensembl: ENSG00000196542
Chromosome: 3
Canonical length: 76 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Serine palmitoyltransferase (SPT; EC 2.3.1.50) catalyzes the first committed and rate-limiting step in sphingolipid biosynthesis. SSSPTB is a small SPT subunit that stimulates SPT activity and confers acyl-CoA preference to the SPT catalytic heterodimer of SPTLC1 (MIM 605712) and either SPTLC2 (MIM 605713) or SPTLC3 (MIM 611120) (Han et al., 2009 [PubMed 19416851]).[supplied by OMIM, Nov 2010]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>Q8NFR3|SPTSSB
     1  MDLRRVKEYF SWLYYQYQII SCCAVLEPWE RSMFNTILLT IIAMVVYTAY VFIPIHIRLA
    61  WEFFSKICGY HSTISN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPTSSB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

stomach: 67 nTPM
urinary bladder: 63 nTPM
skin: 59 nTPM
prostate: 19 nTPM
cerebellum: 15 nTPM
salivary gland: 15 nTPM

Single-cell type

urothelial cells: 305 nCPM
foveolar cells: 215 nCPM
prostatic glandular cells: 213 nCPM
esophageal apical cells: 176 nCPM
prostatic club cells: 130 nCPM
salivary duct cells: 76 nCPM

Immune cell

NK-cell: 330 nTPM
MAIT T-cell: 25 nTPM
gdT-cell: 6.8 nTPM
memory CD8 T-cell: 2.4 nTPM
total PBMC: 2.1 nTPM
memory CD4 T-cell: 0.8 nTPM

Brain region

cerebral cortex: 21 nTPM
thalamus: 15 nTPM
cerebellum: 13 nTPM
white matter: 12 nTPM
midbrain: 12 nTPM
pons: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPTSSB.

Disease | ImmuneIEDB

Conditions an epitope on SPTSSB was assayed in.

lymphoid leukemia T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

serine C-palmitoyltransferase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPTSSB as an antibody target. Whether an autoantibody or antibody against SPTSSB could matter depends on whether native SPTSSB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPTSSB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPTSSB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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