Seroatlas · Human Serome Atlas

SPRR5

Small proline-rich protein 5

Also known as: SPRR5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTR4
Gene
SPRR5
Ensembl
ENSG00000283227
Chromosome
1
Canonical length
108 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Involved in positive regulation of keratinocyte differentiation. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>A0A1B0GTR4|SPRR5
     1  MSQQKQKQCA PPQQCCPPPQ QRCPPPQQCC PPPQQCCPPP QQCCPPPQQC CPPPQQCCPP
    61  PQQCCPPPQQ YCPPPQQTKQ PCQPPPKCQE PCAPKCPPPQ QCQTSKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRR5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.68
Highest tissue expression
111 nTPM

Expression across tissuesHPA

Tissue

  • skin: 111 nTPM
  • breast: 5 nTPM
  • esophagus: 4 nTPM
  • vagina: 3.1 nTPM
  • cervix: 2.2 nTPM
  • skeletal muscle: 0.7 nTPM

Single-cell type

  • esophageal apical cells: 129 nCPM
  • esophageal suprabasal cells: 9.2 nCPM
  • suprabasal keratinocytes: 2.7 nCPM
  • esophageal basal cells: 1 nCPM
  • transitional alveolar cells: 0.9 nCPM
  • late spermatids: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRR5 as an antibody target. Whether an autoantibody or antibody against SPRR5 could matter depends on whether native SPRR5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRR5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRR5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRR5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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