Seroatlas · Human Serome Atlas

SPRR4

Small proline-rich protein 4

Also known as: SPRR4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PI1
Gene
SPRR4
Ensembl
ENSG00000184148
Chromosome
1
Canonical length
79 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in keratinization. Predicted to be located in cell cortex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>Q96PI1|SPRR4
     1  MSSQQQQRQQ QQCPPQRAQQ QQVKQPCQPP PVKCQETCAP KTKDPCAPQV KKQCPPKGTI
    61  IPAQQKCPSA QQASKSKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.71
Highest tissue expression
136 nTPM

Expression across tissuesHPA

Tissue

  • skin: 136 nTPM
  • testis: 6.8 nTPM
  • breast: 5.8 nTPM
  • cervix: 1.8 nTPM
  • vagina: 1.8 nTPM
  • esophagus: 1.1 nTPM

Single-cell type

  • late spermatids: 120 nCPM
  • early spermatids: 13 nCPM
  • esophageal apical cells: 5.9 nCPM
  • late primary spermatocytes: 5.7 nCPM
  • esophageal suprabasal cells: 1.1 nCPM
  • early primary spermatocytes: 0.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.77
gnomAD pLI
0.04
gnomAD missense Z
-1.11
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRR4 as an antibody target. Whether an autoantibody or antibody against SPRR4 could matter depends on whether native SPRR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRR4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRR4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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