SPRR3
Small proline-rich protein 3
Also known as: SPRR3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UBC9
- Gene
- SPRR3
- Ensembl
- ENSG00000163209
- Chromosome
- 1
- Canonical length
- 169 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins
OverviewNCBI Gene
Predicted to enable structural molecule activity. Predicted to be involved in keratinocyte differentiation and wound healing. Located in Golgi apparatus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
169 residues, UniProt reviewed canonical sequence.
>Q9UBC9|SPRR3
1 MSSYQQKQTF TPPPQLQQQQ VKQPSQPPPQ EIFVPTTKEP CHSKVPQPGN TKIPEPGCTK
61 VPEPGCTKVP EPGCTKVPEP GCTKVPEPGC TKVPEPGCTK VPEPGYTKVP EPGSIKVPDQ
121 GFIKFPEPGA IKVPEQGYTK VPVPGYTKLP EPCPSTVTPG PAQQKTKQKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
- Highest tissue expression
- 18,307 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 18,307 nTPM
- vagina: 6,111 nTPM
- cervix: 5,402 nTPM
- salivary gland: 2,903 nTPM
- tonsil: 2,250 nTPM
- urinary bladder: 61 nTPM
Single-cell type
- esophageal apical cells: 490,165 nCPM
- esophageal suprabasal cells: 41,644 nCPM
- suprabasal keratinocytes: 13,013 nCPM
- esophageal basal cells: 777 nCPM
- submucosal glandular cells: 632 nCPM
- myosatellite cells: 192 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- 0.15
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRR3 as an antibody target. Whether an autoantibody or antibody against SPRR3 could matter depends on whether native SPRR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRR3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPRR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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