SPRR1B
Cornifin-B
Also known as: GADD33, SPR1B_HUMAN, SPRR1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P22528
- Gene
- SPRR1B
- Ensembl
- ENSG00000169469
- Chromosome
- 1
- Canonical length
- 89 aa
- Protein class
- Cancer-related genes, Predicted intracellular proteins
OverviewNCBI Gene
The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]
Canonical amino-acid sequenceUniProt
89 residues, UniProt reviewed canonical sequence.
>P22528|SPRR1B
1 MSSQQQKQPC TPPPQLQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH PKVPEPCQPK
61 VPEPCHPKVP EPCPSIVTPA PAQQKTKQKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRR1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.73
- Highest tissue expression
- 2,177 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 2,177 nTPM
- vagina: 1,767 nTPM
- cervix: 1,541 nTPM
- salivary gland: 664 nTPM
- skin: 517 nTPM
- tonsil: 374 nTPM
Single-cell type
- esophageal apical cells: 37,247 nCPM
- esophageal suprabasal cells: 8,162 nCPM
- suprabasal keratinocytes: 1,839 nCPM
- esophageal basal cells: 769 nCPM
- ocular epithelial cells: 216 nCPM
- basal keratinocytes: 88 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.64
- DepMap mean gene effect
- -0.58
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRR1B as an antibody target. Whether an autoantibody or antibody against SPRR1B could matter depends on whether native SPRR1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRR1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPRR1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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