Seroatlas · Human Serome Atlas

SPRR1A

Cornifin-A

Also known as: SPR1A_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P35321
Gene
SPRR1A
Ensembl
ENSG00000169474
Chromosome
1
Canonical length
89 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

A structural constituent of skin epidermis. Involved in keratinocyte differentiation and peptide cross-linking. Located in cornified envelope. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>P35321|SPRR1A
     1  MNSQQQKQPC TPPPQPQQQQ VKQPCQPPPQ EPCIPKTKEP CHPKVPEPCH PKVPEPCQPK
    61  VPEPCQPKVP EPCPSTVTPA PAQQKTKQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRR1A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.74
Highest tissue expression
3,332 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 3,332 nTPM
  • vagina: 1,903 nTPM
  • cervix: 1,194 nTPM
  • salivary gland: 791 nTPM
  • tonsil: 538 nTPM
  • skin: 231 nTPM

Single-cell type

  • esophageal apical cells: 97,190 nCPM
  • esophageal suprabasal cells: 10,608 nCPM
  • suprabasal keratinocytes: 1,436 nCPM
  • esophageal basal cells: 297 nCPM
  • ocular epithelial cells: 199 nCPM
  • submucosal glandular cells: 81 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 0.6 nTPM
  • spinal cord: 0.3 nTPM
  • cerebellum: 0.2 nTPM
  • white matter: 0.2 nTPM
  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.87
gnomAD pLI
0.01
gnomAD missense Z
-0.69
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRR1A as an antibody target. Whether an autoantibody or antibody against SPRR1A could matter depends on whether native SPRR1A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRR1A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRR1A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRR1A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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