SPRN
Shadow of prion protein
Also known as: bA108K14.1, FLJ41197, Shadoo, SPRN_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5BIV9
- Gene
- SPRN
- Ensembl
- ENSG00000203772
- Chromosome
- 10
- Canonical length
- 151 aa
- Protein class
- Predicted intracellular proteins, Transporters
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Predicted to enable nucleic acid binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
151 residues, UniProt reviewed canonical sequence.
>Q5BIV9|SPRN
1 MNWAPATCWA LLLAAAFLCD SGAAKGGRGG ARGSARGGVR GGARGASRVR VRPAQRYGAP
61 GSSLRVAAAG AAAGAAAGAA AGLAAGSGWR RAAGPGERGL EDEEDGVPGG NGTGPGIYSY
121 RAWTSGAGPT RGPRLCLVLG GALGALGLLR PLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.69
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 13 nTPM
- liver: 7.3 nTPM
- cerebellum: 6.9 nTPM
- hippocampal formation: 5.5 nTPM
- amygdala: 3.6 nTPM
- basal ganglia: 3.4 nTPM
Single-cell type
- retinal amacrine cells: 9.5 nCPM
- brain excitatory neurons: 8.5 nCPM
- oligodendrocyte progenitor cells: 7.6 nCPM
- brain inhibitory neurons: 7.3 nCPM
- other brain neurons: 5.8 nCPM
- cardiomyocytes: 4 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 30 nTPM
- hippocampal formation: 26 nTPM
- amygdala: 23 nTPM
- basal ganglia: 23 nTPM
- cerebellum: 22 nTPM
- white matter: 18 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0.29
- gnomAD missense Z
- -1.9
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Shadow of prion protein
- Shadow of prion protein, neuroprotective
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRN as an antibody target. Whether an autoantibody or antibody against SPRN could matter depends on whether native SPRN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRN is annotated at the cell surface, where native SPRN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SPRN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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