SPP2
Secreted phosphoprotein 24
Also known as: SPP24, SPP24_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q13103
- Gene
- SPP2
- Ensembl
- ENSG00000072080
- Chromosome
- 2
- Canonical length
- 211 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This gene encodes a secreted phosphoprotein that is a member of the cystatin superfamily. [provided by RefSeq, Oct 2008]
Canonical amino-acid sequenceUniProt
211 residues, UniProt reviewed canonical sequence.
>Q13103|SPP2
1 MISRMEKMTM MMKILIMFAL GMNYWSCSGF PVYDYDPSSL RDALSASVVK VNSQSLSPYL
61 FRAFRSSLKR VEVLDENNLV MNLEFSIRET TCRKDSGEDP ATCAFQRDYY VSTAVCRSTV
121 KVSAQQVQGV HARCSWSSST SESYSSEEMI FGDMLGSHKW RNNYLFGLIS DESISEQFYD
181 RSLGIMRRVL PPGNRRYPNH RHRARINTDF ELocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 485 nTPM
Expression across tissuesHPA
Tissue
- liver: 485 nTPM
- kidney: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- hepatocytes: 359 nCPM
- cholangiocytes: 6 nCPM
- kupffer cells: 2 nCPM
- ependymal cells: 0.9 nCPM
- mucous neck cells: 0.8 nCPM
- retinal amacrine cells: 0.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- midbrain: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about SPP2.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 212 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.89
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.39
- DepMap mean gene effect
- 0.11
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Cystatin superfamily
- Secreted phosphoprotein 24
- Secreted phosphoprotein 24 (Spp-24) cystatin-like domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPP2 as an antibody target. Whether an autoantibody or antibody against SPP2 could matter depends on whether native SPP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPP2 is annotated as secreted, so native SPP2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SPP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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