Seroatlas · Human Serome Atlas

SPON1

Spondin-1

Also known as: f-spondin, KIAA0762, SPON1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCB6
Gene
SPON1
Ensembl
ENSG00000262655
Chromosome
11
Canonical length
807 aa
Protein class
Plasma proteins, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to enable LBD domain binding activity and metal ion binding activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within negative regulation of amyloid-beta formation; positive regulation of amyloid precursor protein catabolic process; and positive regulation of protein processing. Located in collagen-containing extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

807 residues, UniProt reviewed canonical sequence.

>Q9HCB6|SPON1
     1  MRLSPAPLKL SRTPALLALA LPLAAALAFS DETLDKVPKS EGYCSRILRA QGTRREGYTE
    61  FSLRVEGDPD FYKPGTSYRV TLSAAPPSYF RGFTLIALRE NREGDKEEDH AGTFQIIDEE
   121  ETQFMSNCPV AVTESTPRRR TRIQVFWIAP PAGTGCVILK ASIVQKRIIY FQDEGSLTKK
   181  LCEQDSTFDG VTDKPILDCC ACGTAKYRLT FYGNWSEKTH PKDYPRRANH WSAIIGGSHS
   241  KNYVLWEYGG YASEGVKQVA ELGSPVKMEE EIRQQSDEVL TVIKAKAQWP AWQPLNVRAA
   301  PSAEFSVDRT RHLMSFLTMM GPSPDWNVGL SAEDLCTKEC GWVQKVVQDL IPWDAGTDSG
   361  VTYESPNKPT IPQEKIRPLT SLDHPQSPFY DPEGGSITQV ARVVIERIAR KGEQCNIVPD
   421  NVDDIVADLA PEEKDEDDTP ETCIYSNWSP WSACSSSTCD KGKRMRQRML KAQLDLSVPC
   481  PDTQDFQPCM GPGCSDEDGS TCTMSEWITW SPCSISCGMG MRSRERYVKQ FPEDGSVCTL
   541  PTEETEKCTV NEECSPSSCL MTEWGEWDEC SATCGMGMKK RHRMIKMNPA DGSMCKAETS
   601  QAEKCMMPEC HTIPCLLSPW SEWSDCSVTC GKGMRTRQRM LKSLAELGDC NEDLEQVEKC
   661  MLPECPIDCE LTEWSQWSEC NKSCGKGHVI RTRMIQMEPQ FGGAPCPETV QRKKCRIRKC
   721  LRNPSIQKLR WREARESRRS EQLKEESEGE QFPGCRMRPW TAWSECTKLC GGGIQERYMT
   781  VKKRFKSSQF TSCKDKKEIR ACNVHPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPON1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • gallbladder: 95 nTPM
  • fallopian tube: 59 nTPM
  • retina: 59 nTPM
  • ovary: 56 nTPM
  • adipose tissue: 51 nTPM
  • urinary bladder: 48 nTPM

Single-cell type

  • müller glia: 559 nCPM
  • astrocytes: 546 nCPM
  • thymocytes: 361 nCPM
  • adipocytes: 291 nCPM
  • epicardial cells: 291 nCPM
  • pituicytes/fscs: 231 nCPM

Immune cell

  • MAIT T-cell: 3.3 nTPM
  • memory CD4 T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • gdT-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM

Brain region

  • thalamus: 67 nTPM
  • midbrain: 66 nTPM
  • basal ganglia: 66 nTPM
  • hypothalamus: 56 nTPM
  • hippocampal formation: 54 nTPM
  • medulla oblongata: 52 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPON1 as an antibody target. Whether an autoantibody or antibody against SPON1 could matter depends on whether native SPON1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPON1 is annotated as secreted, so native SPON1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPON1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPON1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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