Seroatlas · Human Serome Atlas

SPOCK3

Testican-3

Also known as: testican-3, TICN3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BQ16
Gene: SPOCK3
Ensembl: ENSG00000196104
Chromosome: 4
Canonical length: 436 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to extracellular matrix

OverviewNCBI Gene

This gene encodes a member of a novel family of calcium-binding proteoglycan proteins that contain thyroglobulin type-1 and Kazal-like domains. The encoded protein and may play a role in adult T-cell leukemia by inhibiting the activity of membrane-type matrix metalloproteinases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

436 residues, UniProt reviewed canonical sequence.

>Q9BQ16|SPOCK3
     1  MLKVSAVLCV CAAAWCSQSL AAAAAVAAAG GRSDGGNFLD DKQWLTTISQ YDKEVGQWNK
    61  FRDEVEDDYF RTWSPGKPFD QALDPAKDPC LKMKCSRHKV CIAQDSQTAV CISHRRLTHR
   121  MKEAGVDHRQ WRGPILSTCK QCPVVYPSPV CGSDGHTYSF QCKLEYQACV LGKQISVKCE
   181  GHCPCPSDKP TSTSRNVKRA CSDLEFREVA NRLRDWFKAL HESGSQNKKT KTLLRPERSR
   241  FDTSILPICK DSLGWMFNRL DTNYDLLLDQ SELRSIYLDK NEQCTKAFFN SCDTYKDSLI
   301  SNNEWCYCFQ RQQDPPCQTE LSNIQKRQGV KKLLGQYIPL CDEDGYYKPT QCHGSVGQCW
   361  CVDRYGNEVM GSRINGVADC AIDFEISGDF ASGDFHEWTD DEDDEDDIMN DEDEIEDDDE
   421  DEGDDDDGGD DHDVYI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPOCK3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 165 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 165 nTPM
spinal cord: 127 nTPM
midbrain: 86 nTPM
hippocampal formation: 77 nTPM
basal ganglia: 70 nTPM
prostate: 69 nTPM

Single-cell type

oligodendrocytes: 1,829 nCPM
bergmann glia: 1,252 nCPM
brain inhibitory neurons: 939 nCPM
retinal amacrine cells: 763 nCPM
adrenal medulla cells: 723 nCPM
oligodendrocyte progenitor cells: 496 nCPM

Immune cell

myeloid DC: 1.8 nTPM
classical monocyte: 1.2 nTPM
intermediate monocyte: 0.6 nTPM
plasmacytoid DC: 0.5 nTPM
total PBMC: 0.5 nTPM
NK-cell: 0.1 nTPM

Brain region

white matter: 261 nTPM
basal ganglia: 148 nTPM
medulla oblongata: 144 nTPM
pons: 122 nTPM
cerebellum: 122 nTPM
spinal cord: 122 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.01
gnomAD missense Z: 0.39
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPOCK3 as an antibody target. Whether an autoantibody or antibody against SPOCK3 could matter depends on whether native SPOCK3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPOCK3 is annotated as secreted, so native SPOCK3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPOCK3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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