Seroatlas · Human Serome Atlas

SPOCK2

Testican-2

Also known as: KIAA0275, testican-2, TICN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92563
Gene: SPOCK2
Ensembl: ENSG00000107742
Chromosome: 10
Canonical length: 424 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

424 residues, UniProt reviewed canonical sequence.

>Q92563|SPOCK2
     1  MRAPGCGRLV LPLLLLAAAA LAEGDAKGLK EGETPGNFME DEQWLSSISQ YSGKIKHWNR
    61  FRDEVEDDYI KSWEDNQQGD EALDTTKDPC QKVKCSRHKV CIAQGYQRAM CISRKKLEHR
   121  IKQPTVKLHG NKDSICKPCH MAQLASVCGS DGHTYSSVCK LEQQACLSSK QLAVRCEGPC
   181  PCPTEQAATS TADGKPETCT GQDLADLGDR LRDWFQLLHE NSKQNGSASS VAGPASGLDK
   241  SLGASCKDSI GWMFSKLDTS ADLFLDQTEL AAINLDKYEV CIRPFFNSCD TYKDGRVSTA
   301  EWCFCFWREK PPCLAELERI QIQEAAKKKP GIFIPSCDED GYYRKMQCDQ SSGDCWCVDQ
   361  LGLELTGTRT HGSPDCDDIV GFSGDFGSGV GWEDEEEKET EEAGEEAEEE EGEAGEADDG
   421  GYIW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPOCK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 219 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 219 nTPM
basal ganglia: 144 nTPM
hypothalamus: 143 nTPM
cerebral cortex: 125 nTPM
thymus: 107 nTPM
midbrain: 102 nTPM

Single-cell type

alveolar cells type 1: 817 nCPM
podocytes: 502 nCPM
t-cells: 240 nCPM
bergmann glia: 191 nCPM
innate lymphoid cells: 190 nCPM
brain inhibitory neurons: 116 nCPM

Immune cell

MAIT T-cell: 80 nTPM
T-reg: 63 nTPM
memory CD4 T-cell: 46 nTPM
gdT-cell: 46 nTPM
naive CD8 T-cell: 40 nTPM
naive CD4 T-cell: 38 nTPM

Brain region

pons: 495 nTPM
thalamus: 474 nTPM
medulla oblongata: 403 nTPM
midbrain: 372 nTPM
cerebellum: 366 nTPM
amygdala: 358 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.24
gnomAD missense Z: 1.13
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPOCK2 as an antibody target. Whether an autoantibody or antibody against SPOCK2 could matter depends on whether native SPOCK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPOCK2 is annotated as secreted, so native SPOCK2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPOCK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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