Seroatlas · Human Serome Atlas

SPOCK1

Testican-1

Also known as: SPOCK, testican-1, TIC1, TICN1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08629
Gene: SPOCK1
Ensembl: ENSG00000152377
Chromosome: 5
Canonical length: 439 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Subcellular location: Vesicles
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

439 residues, UniProt reviewed canonical sequence.

>Q08629|SPOCK1
     1  MPAIAVLAAA AAAWCFLQVE SRHLDALAGG AGPNHGNFLD NDQWLSTVSQ YDRDKYWNRF
    61  RDDDYFRNWN PNKPFDQALD PSKDPCLKVK CSPHKVCVTQ DYQTALCVSR KHLLPRQKKG
   121  NVAQKHWVGP SNLVKCKPCP VAQSAMVCGS DGHSYTSKCK LEFHACSTGK SLATLCDGPC
   181  PCLPEPEPPK HKAERSACTD KELRNLASRL KDWFGALHED ANRVIKPTSS NTAQGRFDTS
   241  ILPICKDSLG WMFNKLDMNY DLLLDPSEIN AIYLDKYEPC IKPLFNSCDS FKDGKLSNNE
   301  WCYCFQKPGG LPCQNEMNRI QKLSKGKSLL GAFIPRCNEE GYYKATQCHG STGQCWCVDK
   361  YGNELAGSRK QGAVSCEEEQ ETSGDFGSGG SVVLLDDLEY ERELGPKDKE GKLRVHTRAV
   421  TEDDEDEDDD KEDEVGYIW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPOCK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 173 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 173 nTPM
cerebral cortex: 116 nTPM
hippocampal formation: 77 nTPM
prostate: 62 nTPM
spinal cord: 60 nTPM
basal ganglia: 51 nTPM

Single-cell type

podocytes: 2,117 nCPM
oligodendrocytes: 1,143 nCPM
müller glia: 694 nCPM
sertoli cells: 658 nCPM
brain excitatory neurons: 589 nCPM
prostatic glandular cells: 542 nCPM

Immune cell

classical monocyte: 0.5 nTPM
myeloid DC: 0.3 nTPM
neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

white matter: 372 nTPM
cerebellum: 293 nTPM
cerebral cortex: 267 nTPM
thalamus: 241 nTPM
hippocampal formation: 235 nTPM
pons: 212 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.83
gnomAD missense Z: 1.18
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPOCK1 as an antibody target. Whether an autoantibody or antibody against SPOCK1 could matter depends on whether native SPOCK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPOCK1 is annotated as secreted, so native SPOCK1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPOCK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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