Seroatlas · Human Serome Atlas

SPMIP7

Protein SPMIP7

Also known as: C7orf72, SMIP7_HUMAN, SPATA48

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D263
Gene: SPMIP7
Ensembl: ENSG00000164500
Chromosome: 7
Canonical length: 438 aa
Protein class: Predicted intracellular proteins
Subcellular location: Connecting piece,Mid piece,Principal piece

OverviewNCBI Gene

Predicted to be involved in spermatogenesis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>A4D263|SPMIP7
     1  MDVEIQDTPG KISISKRSIL SGTVENIDYP HYCDLLRKMN MPFVKGLENR HNYGRFEKKC
    61  NPAFLKFHPY PPSVLPDYHL HDPYPPPYGP HYPLFPLRDD VTLGDSCSGF MSPGGDADLN
   121  PGIGRTIPTL VDFSDVKPQH RVPRPDTGFQ TTIKRQKILS EELQQNRRWN SREVPDISIR
   181  ARLGGWTSPL KVTPLQPHHE GRSLSHIFTF DEEATCTDEG EPLVQTNKKC NAKDSFYKSS
   241  TQKAYEDVPW DKMLPPKLVP EETTLEKTAD PISQCFTLKR YKGVPAITQM VGELWDRFQT
   301  RSFLAPVKPI NFVSSSSRSK YIPLYTGHVQ STNADDVDNP LGDIASLAKQ RYSKPLYTNT
   361  SRAANIPGYT GKVHFTATHP ANSNIPSTTP SPDSELHRVF QKEMAVDLFR HQAPLSRLVT
   421  TVRPYNPFNK KDKETIDY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMIP7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 4.1 nTPM

Expression across tissuesHPA

Tissue

testis: 4.1 nTPM
basal ganglia: 0.4 nTPM
amygdala: 0.2 nTPM
duodenum: 0.1 nTPM
lymph node: 0.1 nTPM
tonsil: 0.1 nTPM

Single-cell type

late primary spermatocytes: 87 nCPM
early spermatids: 61 nCPM
late spermatids: 37 nCPM
renal connecting tubule cells: 2.5 nCPM
foveolar cells: 2.1 nCPM
breast myoepithelial cells: 1.7 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

pons: 0.3 nTPM
medulla oblongata: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM
midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.29
gnomAD pLI: 0
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Protein domainsUniProt · Pfam · InterPro

Spermatogenesis-associated protein 48
Spermatogenesis-associated protein 48

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMIP7 as an antibody target. Whether an autoantibody or antibody against SPMIP7 could matter depends on whether native SPMIP7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMIP7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMIP7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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