Seroatlas · Human Serome Atlas

SPMIP6

Sperm microtubule inner protein 6

Also known as: bA573M23.4, C9orf24, CBE1, MGC32921, MGC33614, NYD-SP22, SMIP6_HUMAN, SMRP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NCR6
Gene: SPMIP6
Ensembl: ENSG00000164972
Chromosome: 9
Canonical length: 262 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol,Equatorial segment,Principal piece

OverviewNCBI Gene

This gene encodes a nuclear- or perinuclear-localized protein with no predicted domains or similarity to other known proteins. Expression of this gene is induced during the differentiation of bronchial epithelial cells, and the encoded protein may play a role in ciliogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

262 residues, UniProt reviewed canonical sequence.

>Q8NCR6|SPMIP6
     1  MFLFSRKTRT PISTYSDSYR APTSIKEVYK DPPLCAWEAN KFLTPGLTHT MERHVDPEAL
    61  QKMAKCAVQD YTYRGSISGH PYLPEKYWLS QEEADKCSPN YLGSDWYNTW RMEPYNSSCC
   121  NKYTTYLPRL PKEARMETAV RGMPLECPPR PERLNAYERE VMVNMLNSLS RNQQLPRITP
   181  RCGCVDPLPG RLPFHGYESA CSGRHYCLRG MDYYASGAPC TDRRLRPWCR EQPTMCTSLR
   241  APARNAVCCY NSPAVILPIS EP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMIP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 226 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 226 nTPM
fallopian tube: 102 nTPM
testis: 74 nTPM
basal ganglia: 61 nTPM
amygdala: 40 nTPM
cerebral cortex: 37 nTPM

Single-cell type

late spermatids: 4,569 nCPM
fallopian tube ciliated cells: 2,178 nCPM
respiratory ciliated cells: 1,669 nCPM
epididymal efferent duct ciliated cells: 1,288 nCPM
endometrial ciliated cells: 890 nCPM
early spermatids: 861 nCPM

Immune cell

naive CD4 T-cell: 0.8 nTPM
T-reg: 0.4 nTPM
gdT-cell: 0.3 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
NK-cell: 0.2 nTPM

Brain region

choroid plexus: 205 nTPM
midbrain: 61 nTPM
medulla oblongata: 52 nTPM
spinal cord: 49 nTPM
basal ganglia: 32 nTPM
white matter: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

alpha-tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sperm microtubule inner protein 6
Spermatid-specific manchette-related protein 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMIP6 as an antibody target. Whether an autoantibody or antibody against SPMIP6 could matter depends on whether native SPMIP6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMIP6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMIP6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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