Seroatlas · Human Serome Atlas

SPMIP5

Sperm-associated microtubule inner protein 5

Also known as: C10orf82, Em:AC016825.4, MGC33547, SMIP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WW14
Gene: SPMIP5
Ensembl: ENSG00000165863
Chromosome: 10
Canonical length: 234 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Predicted to be located in several cellular components, including cytoskeleton; motile cilium; and nucleus. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>Q8WW14|SPMIP5
     1  MEPSKTFMRN LPITPGYSGF VPFLSCQGMS KEDDMNHCVK TFQEKTQRYK EQLRELCCAV
    61  ATAPKLKPVN SEETVLQALH QYNLQYHPLI LECKYVKKPL QEPPIPGWAG YLPRAKVTEF
   121  GCGTRYTVMA KNCYKDFLEI TERAKKAHLK PYEEIYGVSS TKTSAPSPKV LQHEELLPKY
   181  PDFSIPDGSC PALGRPLRED PKTPLTCGCA QRPSIPCSGK MYLEPLSSAK YAEG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMIP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 69 nTPM

Expression across tissuesHPA

Tissue

testis: 69 nTPM
ovary: 3.5 nTPM
hypothalamus: 1.7 nTPM
adrenal gland: 1.4 nTPM
thyroid gland: 1.4 nTPM
pancreas: 1 nTPM

Single-cell type

late spermatids: 2,527 nCPM
early spermatids: 1,246 nCPM
late primary spermatocytes: 222 nCPM
oocytes: 51 nCPM
schwann cells: 10 nCPM
adrenal cortex cells: 7.7 nCPM

Immune cell

basophil: 10 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 2 nTPM
midbrain: 1.1 nTPM
pons: 0.8 nTPM
medulla oblongata: 0.7 nTPM
basal ganglia: 0.6 nTPM
thalamus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0.01
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sperm-associated microtubule inner protein 5
Sperm-associated microtubule inner protein 5 domain
Sperm-associated microtubule inner protein 5

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMIP5 as an antibody target. Whether an autoantibody or antibody against SPMIP5 could matter depends on whether native SPMIP5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMIP5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMIP5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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