SPMIP3
Protein SPMIP3
Also known as: C1orf100, SMIP3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5SVJ3
- Gene
- SPMIP3
- Ensembl
- ENSG00000173728
- Chromosome
- 1
- Canonical length
- 147 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies,Cytosol,Calyx
OverviewNCBI Gene
No narrative summary is available for SPMIP3 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
147 residues, UniProt reviewed canonical sequence.
>Q5SVJ3|SPMIP3
1 MTAIRLREFI ERRPVIPPSI FIAHQGRDVQ GYYPGQLARL HFDHSAKRAP RPLIDLTIPP
61 KTKYHYQPQL DQQTLIRYIC LRRHSKPAEP WYKETTYRRD YSLPFYEIDW NQKLATVSLN
121 PRPLNSLPEL YCCEERSSFE RNAFKLKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPMIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 21 nTPM
Expression across tissuesHPA
Tissue
- testis: 21 nTPM
- parathyroid gland: 0.5 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
Single-cell type
- early spermatids: 1,633 nCPM
- late spermatids: 1,200 nCPM
- late primary spermatocytes: 138 nCPM
- thymocytes: 13 nCPM
- ependymal cells: 9.2 nCPM
- epicardial cells: 4.5 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.6 nTPM
- hypothalamus: 0.6 nTPM
- hippocampal formation: 0.5 nTPM
- midbrain: 0.5 nTPM
- spinal cord: 0.5 nTPM
- white matter: 0.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.54
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.09
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Sperm-associated microtubule inner protein 3
- Family of unknown function (DUF5530)
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPMIP3 as an antibody target. Whether an autoantibody or antibody against SPMIP3 could matter depends on whether native SPMIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPMIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPMIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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