Seroatlas · Human Serome Atlas

SPMIP2

Protein SPMIP2

Also known as: C4orf45, FLJ25371, SMIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96LM5
Gene
SPMIP2
Ensembl
ENSG00000164123
Chromosome
4
Canonical length
186 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mid piece,Principal piece

OverviewNCBI Gene

No narrative summary is available for SPMIP2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

186 residues, UniProt reviewed canonical sequence.

>Q96LM5|SPMIP2
     1  MASVSYQKPT STTVGKQMIF TGPDYIKDYL PKIHQHTSYV GEQHLALEKT GDLRYLWRPA
    61  SNRSLPAKYK HEYVSEIGWR IPQYNFINKS RLGSGFHIKY EELSQASLDS ITHRYQNPWQ
   121  PKPHVLDMQG KQSRASFAWH MSAFEDTDQR NSKWAILVRQ CKSSLPRASK PPKLPKLPKK
   181  EKKRKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
9.9 nTPM

Expression across tissuesHPA

Tissue

  • testis: 9.9 nTPM
  • bone marrow: 0.5 nTPM
  • retina: 0.2 nTPM
  • adipose tissue: 0.1 nTPM
  • thyroid gland: 0.1 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • early spermatids: 424 nCPM
  • late primary spermatocytes: 350 nCPM
  • cardiomyocytes: 258 nCPM
  • late spermatids: 125 nCPM
  • epicardial cells: 52 nCPM
  • oocytes: 51 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 2 nTPM
  • cerebral cortex: 1.4 nTPM
  • thalamus: 1.3 nTPM
  • choroid plexus: 1.2 nTPM
  • hippocampal formation: 1.2 nTPM
  • basal ganglia: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.59
gnomAD pLI
0
DepMap mean gene effect
0.14
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Protein of unknown function DUF4562
  • Domain of unknown function (DUF4562)

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMIP2 as an antibody target. Whether an autoantibody or antibody against SPMIP2 could matter depends on whether native SPMIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPMIP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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