Seroatlas · Human Serome Atlas

SPMIP11

Sperm microtubule inner protein 11

Also known as: LINC00935, SMI11_HUMAN, TEX49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GTD5
Gene
SPMIP11
Ensembl
ENSG00000257987
Chromosome
12
Canonical length
131 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and sperm flagellum. Predicted to be active in axonemal A tubule inner sheath. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

131 residues, UniProt reviewed canonical sequence.

>A0A1B0GTD5|SPMIP11
     1  MAFFNLYLLG YQNSFQNKKR NTTEETNQKE PEPTRLPPII SKDGNYSVHQ NSHTRYHEAV
    61  RKVLLKTFPN QVFRIPLTDA QNFSFWWSHD PGVRPEETMP WIRSPRHCLI KSAMTRFMDH
   121  SILNDRTFSL Y

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMIP11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • testis: 20 nTPM
  • stomach: 1 nTPM
  • lung: 0.2 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • early spermatids: 392 nCPM
  • late spermatids: 336 nCPM
  • late primary spermatocytes: 87 nCPM
  • gastric chief cells: 13 nCPM
  • cardiomyocytes: 9 nCPM
  • megakaryocytes: 6.2 nCPM

Immune cell

  • myeloid DC: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 0.5 nTPM
  • cerebellum: 0.4 nTPM
  • hippocampal formation: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM
  • pons: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.49
gnomAD pLI
0.01

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Sperm microtubule inner protein 11
  • Sperm microtubule inner protein 11

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMIP11 as an antibody target. Whether an autoantibody or antibody against SPMIP11 could matter depends on whether native SPMIP11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMIP11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMIP11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPMIP11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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