Seroatlas · Human Serome Atlas

SPMIP10

Sperm-associated microtubule inner protein 10

Also known as: C5orf48, FLJ27505, MGC163367, MGC163369, SMI10_HUMAN, TEX43, Tseg7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZNM6
Gene: SPMIP10
Ensembl: ENSG00000196900
Chromosome: 5
Canonical length: 134 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Predicted to be active in axonemal B tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

134 residues, UniProt reviewed canonical sequence.

>Q6ZNM6|SPMIP10
     1  MASGKDTCPT LPKLTNNCSD ESLYKSANKY EEIHLPRFSL KQGMIPRRYV MPWKENMIFR
    61  NVNLKQAEVC GIHTGPLEDS LFLNHSERLC HGEDRKVVFQ KGPPEIKIAD MPLHSPLSRY
   121  QSTVISHGFR RRLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMIP10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

testis: 21 nTPM
colon: 0.5 nTPM
small intestine: 0.2 nTPM
cerebellum: 0.1 nTPM
duodenum: 0.1 nTPM
tongue: 0.1 nTPM

Single-cell type

early spermatids: 656 nCPM
late spermatids: 170 nCPM
late primary spermatocytes: 104 nCPM
paneth cells: 3.9 nCPM
enteric stem cells: 3.6 nCPM
enteric transient amplifying cells: 2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.8 nTPM
cerebral cortex: 0.4 nTPM
white matter: 0.4 nTPM
pons: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

Sperm-associated microtubule inner protein 10
Sperm-associated microtubule inner protein 10

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMIP10 as an antibody target. Whether an autoantibody or antibody against SPMIP10 could matter depends on whether native SPMIP10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMIP10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMIP10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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