Seroatlas · Human Serome Atlas

SPMIP1

Protein SPMIP1

Also known as: ATP6V1FNB, SMIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GUX0
Gene
SPMIP1
Ensembl
ENSG00000272899
Chromosome
7
Canonical length
176 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SPMIP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>A0A1B0GUX0|SPMIP1
     1  MSRQLNIDAL RQNFWKEEYL REKMLRCEWY RKYGSMVKAK QKAKAAARLP LKLPTLHPKA
    61  PLSPPPAPKS APSKVPSPVP EAPFQSEMYP VPPITRALLY EGISHDFQGR YRYLNTRKLD
   121  MPETRYLFPI TTSFTYGWQL GPPVKQELVS CKMCRIESFF RKNGAFALLD PRDLAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 23 nTPM
  • kidney: 12 nTPM
  • skeletal muscle: 10 nTPM
  • heart muscle: 5.8 nTPM
  • amygdala: 4.8 nTPM
  • cerebral cortex: 4.8 nTPM

Single-cell type

  • early spermatids: 430 nCPM
  • late spermatids: 257 nCPM
  • late primary spermatocytes: 100 nCPM
  • retinal pigment epithelial cells: 4.3 nCPM
  • myonuclei: 3.9 nCPM
  • sertoli cells: 3.1 nCPM

Immune cell

  • T-reg: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebellum: 27 nTPM
  • cerebral cortex: 9.4 nTPM
  • amygdala: 8.7 nTPM
  • hippocampal formation: 7.8 nTPM
  • basal ganglia: 6.6 nTPM
  • white matter: 5.7 nTPM

Protein domainsUniProt · Pfam · InterPro

  • Sperm microtubule inner protein 1, C-terminal
  • Sperm microtubule inner protein 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMIP1 as an antibody target. Whether an autoantibody or antibody against SPMIP1 could matter depends on whether native SPMIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPMIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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