Seroatlas · Human Serome Atlas

SPMAP2L

Sperm microtubule associated protein 2-like

Also known as: SMA2L_HUMAN, THEGL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DJG4
Gene: SPMAP2L
Ensembl: ENSG00000249693
Chromosome: 4
Canonical length: 465 aa
Protein class: Predicted intracellular proteins
Subcellular location: Principal piece

OverviewNCBI Gene

No narrative summary is available for SPMAP2L in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>P0DJG4|SPMAP2L
     1  MENQEFLSSS APSEVTDGQV STEISTCSEV FQKPIVLRIL DTHRELEESE DPEKHENPEE
    61  PEEVREQDQR DESEECDEPH ESYEPHAPYA PHKPRDSYAP YELHGPHAAP KLLKAREPRQ
   121  LRHTREPRKS REAKETELLP SAAVMISPSL ITRAPPRPQL SFLGANPVSC DFVRKCFSSR
   181  KRTPNLSKPK KQWGTPDRKL FWGNQDPIRP VSQGALKAQL TKRLENLAQP KEVSCHYVPN
   241  RAQYYHSCGR ESVIWEITPP ALFRQPSKRI QRLSQPNGFK RQCLLNRPFS DNSARDSLRI
   301  SDPSPRILQL SVAKGTDPNY HPSKKMQTKI SLSTLSAIAT PRIIELAHPR IKLEGLCYER
   361  QRSELPIRPV PPAAMIAKPS PRTIALAKSK SVHQDYLPDR DAHWPVSYAT THSKASPRIQ
   421  ELANPNKRAP VRIVYYDPDV FKTKPAALKA QCSQRIWELS QPLTR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMAP2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 3.3 nTPM

Expression across tissuesHPA

Tissue

testis: 3.3 nTPM
smooth muscle: 0.5 nTPM
bone marrow: 0.3 nTPM
skin: 0.3 nTPM
colon: 0.2 nTPM
epididymis: 0.2 nTPM

Single-cell type

early spermatids: 55 nCPM
late primary spermatocytes: 36 nCPM
late spermatids: 33 nCPM
adrenal medulla cells: 11 nCPM
epididymal efferent duct ciliated cells: 10 nCPM
retinal pigment epithelial cells: 8.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1.2 nTPM
midbrain: 1.2 nTPM
hypothalamus: 1.1 nTPM
choroid plexus: 0.9 nTPM
medulla oblongata: 0.8 nTPM
pons: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMAP2L as an antibody target. Whether an autoantibody or antibody against SPMAP2L could matter depends on whether native SPMAP2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMAP2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMAP2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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