Seroatlas · Human Serome Atlas

SPMAP1

Sperm microtubule associated protein 1

Also known as: C17orf98, LOC388381, SPMA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MV24
Gene
SPMAP1
Ensembl
ENSG00000275489
Chromosome
17
Canonical length
154 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for SPMAP1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>A8MV24|SPMAP1
     1  MAYLSECRLR LEKGFILDGV AVSTAARAYG RSRPKLWSAI PPYNAQQDYH ARSYFQSHVV
    61  PPLLRKTDQD HGGTGRDGWI VDYIHIFGQG QRYLNRRNWA GTGHSLQQVT GHDHYNADLK
   121  PIDGFNGRFG YRRNTPALRQ STSVFGEVTH FPLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPMAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • testis: 19 nTPM
  • adipose tissue: 0.2 nTPM
  • choroid plexus: 0.1 nTPM
  • epididymis: 0.1 nTPM
  • skeletal muscle: 0.1 nTPM
  • skin: 0.1 nTPM

Single-cell type

  • early spermatids: 228 nCPM
  • late primary spermatocytes: 169 nCPM
  • late spermatids: 16 nCPM
  • cone photoreceptor cells: 2.1 nCPM
  • sertoli cells: 1.2 nCPM
  • early primary spermatocytes: 0.9 nCPM

Immune cell

  • classical monocyte: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.4 nTPM
  • white matter: 0.4 nTPM
  • cerebellum: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0.01
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

  • Sperm microtubule associated protein 1
  • Sperm microtubule associated protein 1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPMAP1 as an antibody target. Whether an autoantibody or antibody against SPMAP1 could matter depends on whether native SPMAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPMAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPMAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPMAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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