Seroatlas · Human Serome Atlas

SPINK8

Serine protease inhibitor Kazal-type 8

Also known as: ISK8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C7L1
Gene
SPINK8
Ensembl
ENSG00000229453
Chromosome
3
Canonical length
97 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

97 residues, UniProt reviewed canonical sequence.

>P0C7L1|SPINK8
     1  MKGICSDAIL VLATSMWMAF AIDFPLPMAS ERGQLDKTIV ECLKNVNKCW FLSYIKPSEP
    61  ICGSDQVTYS SDCHLCSKIL FEGLNITKLY DGQCENS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPINK8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • breast: 15 nTPM
  • bone marrow: 7.9 nTPM
  • fallopian tube: 6.7 nTPM
  • placenta: 5.2 nTPM
  • retina: 1.7 nTPM
  • testis: 1.6 nTPM

Single-cell type

  • esophageal apical cells: 70 nCPM
  • breast lactating cells: 47 nCPM
  • breast hormone-responsive cells: 22 nCPM
  • neutrophil progenitors: 13 nCPM
  • tuft cells: 12 nCPM
  • neutrophils: 11 nCPM

Immune cell

  • neutrophil: 1.8 nTPM
  • eosinophil: 1.1 nTPM
  • basophil: 0.2 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • non-classical monocyte: 0.2 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • medulla oblongata: 24 nTPM
  • midbrain: 24 nTPM
  • white matter: 24 nTPM
  • cerebellum: 23 nTPM
  • cerebral cortex: 23 nTPM
  • thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.84
gnomAD pLI
0
gnomAD missense Z
0.05
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPINK8 as an antibody target. Whether an autoantibody or antibody against SPINK8 could matter depends on whether native SPINK8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPINK8 is annotated as secreted, so native SPINK8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPINK8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPINK8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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