SPINK6
Serine protease inhibitor Kazal-type 6
Also known as: BUSI2, ISK6_HUMAN, MGC21394, UNQ844
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6UWN8
- Gene
- SPINK6
- Ensembl
- ENSG00000178172
- Chromosome
- 5
- Canonical length
- 80 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted - unknown location
OverviewNCBI Gene
The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]
Canonical amino-acid sequenceUniProt
80 residues, UniProt reviewed canonical sequence.
>Q6UWN8|SPINK6
1 MKLSGMFLLL SLALFCFLTG VFSQGGQVDC GEFQDPKVYC TRESNPHCGS DGQTYGNKCA
61 FCKAIVKSGG KISLKHPGKCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPINK6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 13 nTPM
Expression across tissuesHPA
Tissue
- cervix: 13 nTPM
- cerebellum: 13 nTPM
- vagina: 11 nTPM
- salivary gland: 8.9 nTPM
- thymus: 4.5 nTPM
- esophagus: 2.6 nTPM
Single-cell type
- esophageal apical cells: 28 nCPM
- cardiomyocytes: 8.7 nCPM
- retinal horizontal cells: 4 nCPM
- suprabasal keratinocytes: 3 nCPM
- hofbauer cells: 2.4 nCPM
- cone photoreceptor cells: 2.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 9.2 nTPM
- white matter: 7.4 nTPM
- cerebral cortex: 5.5 nTPM
- pons: 4.6 nTPM
- medulla oblongata: 4.2 nTPM
- midbrain: 3.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.95
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.38
- DepMap mean gene effect
- 0.06
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPINK6 as an antibody target. Whether an autoantibody or antibody against SPINK6 could matter depends on whether native SPINK6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPINK6 is annotated as secreted, so native SPINK6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SPINK6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...