SPINK13
Serine protease inhibitor Kazal-type 13
Also known as: HESPINTOR, ISK13_HUMAN, LiESP6, MGC149260, SPINK5L3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q1W4C9
- Gene
- SPINK13
- Ensembl
- ENSG00000214510
- Chromosome
- 5
- Canonical length
- 94 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm,Plasma membrane
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of acrosome reaction. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
94 residues, UniProt reviewed canonical sequence.
>Q1W4C9|SPINK13
1 MAAFPHKIIF FLVCSTLTHV AFSGIFNKRD FTRWPKPRCK MYIPLDPDYN ADCPNVTAPV
61 CASNGHTFQN ECFFCVEQRE FHYRIKFEKY GKCDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPINK13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 310 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 310 nTPM
- seminal vesicle: 30 nTPM
- blood vessel: 2.4 nTPM
- adrenal gland: 1.9 nTPM
- prostate: 1.8 nTPM
- stomach: 1.5 nTPM
Single-cell type
- epididymal principal cells: 845 nCPM
- epididymal efferent duct absorptive cells: 224 nCPM
- cardiomyocytes: 93 nCPM
- leydig cells: 49 nCPM
- peritubular myoid cells: 43 nCPM
- epicardial cells: 21 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 11 nTPM
- pons: 8.1 nTPM
- medulla oblongata: 8 nTPM
- basal ganglia: 7.5 nTPM
- thalamus: 7.5 nTPM
- cerebral cortex: 7.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.77
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.22
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- negative regulation of acrosome reaction
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPINK13 as an antibody target. Whether an autoantibody or antibody against SPINK13 could matter depends on whether native SPINK13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPINK13 is annotated as secreted, so native SPINK13 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label SPINK13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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