Seroatlas · Human Serome Atlas

SPINK1

Serine protease inhibitor Kazal-type 1

Also known as: ISK1_HUMAN, PCTT, PSTI, Spink3, TATI

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P00995
Gene
SPINK1
Ensembl
ENSG00000164266
Chromosome
5
Canonical length
79 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to digestive system

OverviewNCBI Gene

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>P00995|SPINK1
     1  MKVTGIFLLS ALALLSLSGN TGADSLGREA KCYNELNGCT KIYDPVCGTD GNTYPNECVL
    61  CFENRKRQTS ILIQKSGPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPINK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
49,965 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 49,965 nTPM
  • stomach: 1,627 nTPM
  • urinary bladder: 930 nTPM
  • liver: 687 nTPM
  • rectum: 412 nTPM
  • colon: 400 nTPM

Single-cell type

  • pancreatic acinar cells: 38,910 nCPM
  • gastric progenitor cells: 5,014 nCPM
  • gastric chief cells: 3,855 nCPM
  • urothelial cells: 3,389 nCPM
  • foveolar cells: 3,157 nCPM
  • parietal cells: 2,956 nCPM

Immune cell

  • basophil: 0.3 nTPM
  • neutrophil: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • cerebral cortex: 3.4 nTPM
  • white matter: 2 nTPM
  • choroid plexus: 1.6 nTPM
  • cerebellum: 1.5 nTPM
  • thalamus: 1.5 nTPM
  • pons: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPINK1.

Disease | AllUniProt

Conditions SPINK1 is implicated in, by any mechanism.

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 247 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0.31
gnomAD missense Z
-0.12
DepMap mean gene effect
0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPINK1 as an antibody target. Whether an autoantibody or antibody against SPINK1 could matter depends on whether native SPINK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPINK1 is annotated as secreted, so native SPINK1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label SPINK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPINK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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