Seroatlas · Human Serome Atlas

SPICE1

Spindle and centriole-associated protein 1

Also known as: CCDC52, SPICE, SPICE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N0Z3
Gene
SPICE1
Ensembl
ENSG00000163611
Chromosome
3
Canonical length
855 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome,Basal body

OverviewNCBI Gene

Involved in metaphase chromosome alignment; mitotic spindle assembly; and regulation of centriole replication. Located in intracellular membrane-bounded organelle; microtubule cytoskeleton; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

855 residues, UniProt reviewed canonical sequence.

>Q8N0Z3|SPICE1
     1  MSFVRVNRCG PRVGVRKTPK VKKKKTSVKQ EWDNTVTDLT VHRATPEDLV RRHEIHKSKN
    61  RALVHWELQE KALKRKWRKQ KPETLNLEKR RLSIMKEILS DQYQMQDVLE KSDHLIAAAK
   121  ELFPRRRTGF PNVTVAPDSS QGPIVVNQDP ITQSIFNESV IEPQALNDVD GEEEGTVNSQ
   181  SGESENENEL DNSLNSQSNT NTDRFLQQLT EENFELISKL WTDIQQKIAT QSQITPPGTP
   241  SSALSSGEQR AALNATNAVK RLQTRLQPEE STETLDSSYV VGHVLNSRKQ KQLLNKVKRK
   301  PNLHALSKPK KNISSGSTTS ADLPNRTNSN LDVLKHMIHE VEHEMEEYER WTGREVKGLQ
   361  SSQGLTGFTL SLVSSLCRLV RYLKESEIQL RKEVETRQQL EQVLGDHREL IDALTAEILR
   421  LREENAATQA RLQQYMVTTD EQLISLTHAI KNCPVINNRQ EIQASESGAT GRRVMDSPER
   481  PVVNANVSVP LMFREEVAEF PQEELPVKLS QVPDPPDNMN LAKNFPAHIF EPAVLLTPPR
   541  QKSNLKFSPL QDVLRRTVQT RPAPRLPPTV EIIEKEQNWE EKTLPIDTDI QNSSEENRLF
   601  TQRWRVSHMG EDLENKTQAP FVNLSQPLCN SHSNTQQSRS PTFSEELPVL GDGQQLRTNE
   661  SLIQRKDIMT RIADLTLQNS AIKAHMNNII EPRGEQGDGL RELNKQESAS DMTSTFPVAQ
   721  SLTPGSMEER IAELNRQSME ARGKLLQLIE QQKLVGLNLS PPMSPVQLPL RAWTEGAKRT
   781  IEVSIPGAEA PESSKCSTVS PVSGINTRRS SGATGNSCSP LNATSGSGRF TPLNPRAKIE
   841  KQNEEGWFAL STHVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPICE1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
8 nTPM

Expression across tissuesHPA

Tissue

  • endometrium: 8 nTPM
  • salivary gland: 8 nTPM
  • thymus: 7.8 nTPM
  • cervix: 7.7 nTPM
  • fallopian tube: 7.5 nTPM
  • gallbladder: 7.2 nTPM

Single-cell type

  • ependymal cells: 84 nCPM
  • choroid plexus epithelial cells: 72 nCPM
  • renal connecting tubule cells: 52 nCPM
  • distal convoluted tubule cells: 47 nCPM
  • proximal tubule cells: 46 nCPM
  • renal collecting duct principal cells: 45 nCPM

Immune cell

  • plasmacytoid DC: 9.8 nTPM
  • naive CD4 T-cell: 7 nTPM
  • naive B-cell: 6.2 nTPM
  • memory B-cell: 5.6 nTPM
  • MAIT T-cell: 5.2 nTPM
  • naive CD8 T-cell: 5.2 nTPM

Brain region

  • choroid plexus: 13 nTPM
  • cerebellum: 12 nTPM
  • white matter: 12 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 11 nTPM
  • basal ganglia: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.89
gnomAD pLI
0
gnomAD missense Z
0.35
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Spindle and centriole-associated protein 1
  • Centriole duplication and mitotic chromosome congression

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPICE1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPICE1 as an antibody target. Whether an autoantibody or antibody against SPICE1 could matter depends on whether native SPICE1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPICE1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPICE1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPICE1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...