Seroatlas · Human Serome Atlas

SPEM3

Uncharacterized protein SPEM3

Also known as: SPEM3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A1B0GUW6
Gene: SPEM3
Ensembl: ENSG00000283439
Chromosome: 17
Canonical length: 1196 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility and sperm individualization. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1196 residues, UniProt reviewed canonical sequence.

>A0A1B0GUW6|SPEM3
     1  MGERAYHGAQ VCSGTNPRKC QDLGDSILLL LGSFILLNVW INVVTLLWKH LKSSLRILFR
    61  HFFPKDKQPS GSHPICICSS VDPKNLCSKV SSRVHPRPGF LLRRVNHLDS WIPDTNDEKV
   121  SACCCVPPKC GHAGVPRESA RGLYKAGMMG GGEAPQVTAS KAQASLLSRP ETSSQFPKMS
   181  KLDTGPCHLP QESKTKTPDC APAEAPAQAQ VHSPTHTPVC TPTHPWTRST DHTAVHTPAH
   241  SWTHSKARTP EGTHSQAQDT SAQAQAHTSA PTPAQTPAHI QAHTPAPTPA KASAHTKAHT
   301  SAQAQTHSPP HTPEYTHSQA HSPEHTSAHS PAQAPMPVPA HPQAHAPEYT SAHAPAYIPD
   361  HSHLVRSSVP VPTSAPAPPG TLAPATTPVL APTPAPVPAS APSPAPALVM ALTTTPVPDP
   421  VPATTPAPII TPIPSTPPAF SHDLSTGHVV YDARREKQNF FHMSSPQNPE YSRKDLATLF
   481  RPQEGQDLVS SGISEQTKQC SGDSAKLPAG SILGYLELRN MEWKNSDDAK DKFPQTKTSP
   541  YCSFHPCSSE KNTDSQAPFY PKFLAYSRDT ACAKTCFHSA TTAQSSVCTL PPPFTLSLPL
   601  VPPRSFVPPQ PTNHQRPSTL IQTPTVLPTS KSPQSILTSQ FPIPSLFATI SQPLIQPQCP
   661  ECHESLGLTQ DSGLQRTPGP SKDSRVPRNL DLAQNPDLYK NPGLTQDPGL HENPGLAPNQ
   721  GLHEFPGLPQ DSYLCQNPSP SQDFGLHKNS GITQDSHPQK NTGLTQEAGI LRSPCLTQSP
   781  GLHKKTPFTQ TSDLQRSSGF TQDSGIYRNL EPNQETVIYK NQDLSQATDH QKNLGSSKDS
   841  GGHKNTGNVQ DPGVCSTAGL TEDSGSQKGP YVPQDSEVNK SSGVIQESFL HKSPGLVQTS
   901  GLPKCSGLTQ NSGDYKNPGL IQDCGGHKVK GLTQDSNLPS LTQATKVERR FSLPQDVGVY
   961  RSSEHSQDSN LHKCPGINQD PGPHKDPALV QDSGLPKISG LTQESGPYKS SCLIPDPSLY
  1021  KNPSPALGSD FVQLLSLLQT PKSTLSLMKS SVPEKAAQKE DAQRHVLWAR VQLNENSCPS
  1081  KAQVVSNDLQ TFSEVPVLIE LQSSSWRAGS QHGAYRPVDT VPSGYQNYRQ MSMPTHINWK
  1141  SHCPGPGTQA GHVVFDARQR RLAVGKDKCE ALSPRRLHQE APSNSGKPSR SGDIRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPEM3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 59 nTPM

Expression across tissuesHPA

Tissue

testis: 59 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

early spermatids: 0.8 nCPM
late spermatids: 0.7 nCPM
late primary spermatocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM

OntologyGO

Biological processes

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPEM3 as an antibody target. Whether an autoantibody or antibody against SPEM3 could matter depends on whether native SPEM3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPEM3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPEM3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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