Seroatlas · Human Serome Atlas

SPEM2

Uncharacterized protein SPEM2

Also known as: C17orf74, SPEM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q0P670
Gene: SPEM2
Ensembl: ENSG00000184560
Chromosome: 17
Canonical length: 501 aa
Protein class: Predicted membrane proteins
Subcellular location: Golgi apparatus

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q0P670|SPEM2
     1  MENQLWHNTV RCCNQYQESP HDAEDILLLL LGLIVLVNIG INVATMMWHG LQNALDKMID
    61  WATQKNEIQA SESPPSGPPD KAQDVHIHCI LDPVQVKMSR PTQYSSFSCH HFSNHHSSSL
   121  LRCVRRRRRR HRRCRRRCCN HQQRPQNYRQ IPHSHSVFRN PHRSQKMSQL HRVPFFDQED
   181  PDSYLEEEDN LPFPYPKYPR RGWGGFYQRA GLPSNVGLWG HQGGILASLP PPSLYLSPEL
   241  RCMPKRVEAR SELRLQSYGR HGSQSRLWGN VEAEQWASSP PPPHRLPPNP SWVPVGHSPY
   301  PSVGWMLYDS WDQRRRGTEG FERPPASVSR NARPEAQGCR EHHSPQSHQQ SLLGHAYGQS
   361  HRSPHPSTEP LGYSSQDPRE VRRRAADWAE ALPAWRPLTT SASLTVLDEA SHQRTPAPSS
   421  VLVPHSSQPW PKVQAADPAP PPTMFVPLSR NPGGNANYQV YDSLELKRQV QKSRARSSSL
   481  PPASTSTLRP SLHRSQTEKL N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPEM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 122 nTPM

Expression across tissuesHPA

Tissue

testis: 122 nTPM
retina: 0.2 nTPM
cerebellum: 0.1 nTPM
prostate: 0.1 nTPM
skeletal muscle: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

late spermatids: 1,042 nCPM
early spermatids: 83 nCPM
late primary spermatocytes: 3.8 nCPM
leydig cells: 0.9 nCPM
undifferentiated spermatogonia: 0.8 nCPM
early primary spermatocytes: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
hippocampal formation: 0.1 nTPM
hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPEM2 as an antibody target. Whether an autoantibody or antibody against SPEM2 could matter depends on whether native SPEM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPEM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPEM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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