Seroatlas · Human Serome Atlas

SPDYE8

Speedy protein E8

Also known as: SPD8_HUMAN, SPDYE8P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DUD1
Gene
SPDYE8
Ensembl
ENSG00000273520
Chromosome
7
Canonical length
265 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables acetylcholine receptor regulator activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>P0DUD1|SPDYE8
     1  MGQILGKIMM SHQPQPQEER SPQRSTSGYP LQEVVDDEVS GPSAPGVDPS PPRRSLGWKR
    61  KRECLDESDD EPEKELAPEP EETWVAETLC GLKMKAKRRR VSLVLPEYYE AFNRLLEDPV
   121  IKRLLAWDKD LRVSDKYLLA MVIAYFSRAG LPSWQYQRIH FFLALYLAND MEEDDEAPKQ
   181  NIFYFLYEET RSHIPLLSEL WFQLCRYMNP RARKNCSQIA LFRKYRFHFF CSMRCRAWVS
   241  LEELEEIQAY DPEHWVWARD RAHLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
0.7 nTPM

Expression across tissuesHPA

Tissue

  • testis: 0.7 nTPM
  • placenta: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • enteric stem cells: 0.2 nCPM
  • enteric transient amplifying cells: 0.1 nCPM
  • epididymal principal cells: 0.1 nCPM
  • megakaryocyte progenitors: 0.1 nCPM
  • myonuclei: 0.1 nCPM
  • somatotrophs: 0.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.6 nTPM
  • amygdala: 0.3 nTPM
  • cerebellum: 0.3 nTPM
  • hippocampal formation: 0.3 nTPM
  • hypothalamus: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE8 as an antibody target. Whether an autoantibody or antibody against SPDYE8 could matter depends on whether native SPDYE8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPDYE8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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