Seroatlas · Human Serome Atlas

SPDYE6

Speedy protein E6

Also known as: SPDE6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0CI01
Gene
SPDYE6
Ensembl
ENSG00000260097
Chromosome
7
Canonical length
402 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a cell cycle regulatory protein which plays an important role in cell cycle progression by binding and activating cyclin-dependent kinases. The encoded protein belongs to a family of cyclin-dependent kinase regulators that contain a speedy box domain which is required for cyclin-dependent kinase activation. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>P0CI01|SPDYE6
     1  MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS
    61  PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSSILPEHHK
   121  DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
   181  MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
   241  WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKRWFQ LGHSMNPRAR
   301  KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKHRFQ LYRSMNSRAR KNRSQIVLFQ
   361  KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
3.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 3.4 nTPM
  • skeletal muscle: 1.7 nTPM
  • lymph node: 1 nTPM
  • skin: 1 nTPM
  • bone marrow: 0.8 nTPM
  • spleen: 0.8 nTPM

Single-cell type

  • late spermatids: 30 nCPM
  • cardiomyocytes: 23 nCPM
  • early spermatids: 14 nCPM
  • epicardial cells: 14 nCPM
  • myonuclei: 13 nCPM
  • cholangiocytes: 9.8 nCPM

Immune cell

  • naive B-cell: 0.3 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • white matter: 7.1 nTPM
  • cerebral cortex: 7 nTPM
  • thalamus: 7 nTPM
  • cerebellum: 6.8 nTPM
  • pons: 6.8 nTPM
  • hippocampal formation: 6.3 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE6 as an antibody target. Whether an autoantibody or antibody against SPDYE6 could matter depends on whether native SPDYE6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPDYE6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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