Seroatlas · Human Serome Atlas

SPDYE5

Speedy protein E5

Also known as: SPDE5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NIY4
Gene
SPDYE5
Ensembl
ENSG00000170092
Chromosome
7
Canonical length
402 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. Predicted to be involved in positive regulation of cyclin-dependent protein serine/threonine kinase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>A6NIY4|SPDYE5
     1  MDRTETRFRK RGQITEKITT SRQPQPQNEQ SPQRSTSGYP LQEVVDDEVL GPSAPGVDPS
    61  PPCRSLGWKR KREWSDESAE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSPILPEHHK
   121  GFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
   181  MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
   241  WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYGKNRSR IPLLRKRWFQ LGRSMNPRAR
   301  KKRSRIPLLR KRRFQLGRSM NPRARKNRSR IPLLRKRRFQ LGRSMNLRAR KNRSQIVLFQ
   361  KRRFQFFCSM SGRAWVSPEE LEEIQAYDPE HWVWARDRAH LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
1.2 nTPM

Expression across tissuesHPA

Tissue

  • testis: 1.2 nTPM
  • skin: 0.8 nTPM
  • bone marrow: 0.7 nTPM
  • retina: 0.6 nTPM
  • lymph node: 0.4 nTPM
  • duodenum: 0.3 nTPM

Single-cell type

  • epicardial cells: 57 nCPM
  • cardiomyocytes: 39 nCPM
  • myonuclei: 37 nCPM
  • retinal ganglion cells: 31 nCPM
  • adipocytes: 30 nCPM
  • fibro-adipogenic progenitors: 26 nCPM

Immune cell

  • gdT-cell: 0.2 nTPM
  • basophil: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • neutrophil: 0.1 nTPM

Brain region

  • cerebral cortex: 9.7 nTPM
  • cerebellum: 9 nTPM
  • white matter: 8.4 nTPM
  • thalamus: 7.9 nTPM
  • amygdala: 7.8 nTPM
  • hippocampal formation: 7.7 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE5 as an antibody target. Whether an autoantibody or antibody against SPDYE5 could matter depends on whether native SPDYE5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPDYE5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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