Seroatlas · Human Serome Atlas

SPDYE3

Speedy protein E3

Also known as: SPDE3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKU9
Gene: SPDYE3
Ensembl: ENSG00000214300
Chromosome: 7
Canonical length: 549 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

549 residues, UniProt reviewed canonical sequence.

>A6NKU9|SPDYE3
     1  MTSHQPQPQE EQSPQRSTSG YPLQEVVDDE VSGPSAPGVD PSPPRRSLGC KRKRECLDES
    61  DDEPEKELAP EPEETWVAET LCGLKMKAKR RRVSLVLPEY YEAFNRLLAP GVDPSPPRRS
   121  LGCKRKRECL DESDDEPEKE LAPEPEETWV AETLCGLKMK AKRRRVSLVL PEYYEAFNRL
   181  LAPGVDPSPP RRSLGCKRKR ECLDESDDEP EKELAPEPEE TWVAETLCGL KMKAKRRRVS
   241  LVLPEYYEAF NRLLAPGVDP SPPRRSLGCK RKRECLDESD DEPEKELAPE PEETWVAETL
   301  CGLKMKAKRR RVSLVLPEYY EAFNRLLAPG VDPSPPRRSL GCKRKRECLD ESDDEPEKEL
   361  APEPEETWVA ETLCGLKMKA KRRRVSLVLP EYYEAFNRLL EDPVIKRFLA WDKDLRVSDK
   421  YLLAMVIAYF SRAGLPSWQY QRIHFFLALY LANDMEEDDE APKQKIFYFL YGKTHSHIPL
   481  RPKHWFQLCR PMNPRARKNC SQIALFQKRR FQFFCSMRCR AWVSPEELEE IQAYDPEHWV
   541  WARDRAHLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

testis: 2.4 nTPM
bone marrow: 0.1 nTPM
cerebellum: 0.1 nTPM
liver: 0.1 nTPM
lymph node: 0.1 nTPM
pituitary gland: 0.1 nTPM

Single-cell type

retinal amacrine cells: 50 nCPM
retinal horizontal cells: 44 nCPM
leydig cells: 42 nCPM
retinal bipolar cells: 40 nCPM
ovarian stromal cells: 38 nCPM
adipocytes: 35 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 3.7 nTPM
cerebral cortex: 3.7 nTPM
midbrain: 3.3 nTPM
basal ganglia: 3 nTPM
medulla oblongata: 3 nTPM
pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: -0.63

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

protein kinase binding

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE3 as an antibody target. Whether an autoantibody or antibody against SPDYE3 could matter depends on whether native SPDYE3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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