Seroatlas · Human Serome Atlas

SPDYE2B

Speedy protein E2B

Also known as: SPE2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NHP3
Gene
SPDYE2B
Ensembl
ENSG00000173678
Chromosome
7
Canonical length
402 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

402 residues, UniProt reviewed canonical sequence.

>A6NHP3|SPDYE2B
     1  MDRTETRFRK RGQITGKITT SRQPHPQNEQ SPQRSTSGYP LQEVVDDEML GPSAPGVDPS
    61  PPCRSLGWKR KREWSDESEE EPEKELAPEP EETWVVEMLC GLKMKLKQQR VSSILPEHHK
   121  DFNSQLAPGV DPSPPHRSFC WKRKMEWWDE SEESLEEEPR KVLAPEPEEI WVAEMLCGLK
   181  MKLKRRRVSL VLPEHHEAFN RLLEDPVIKR FLAWDKDLRV SDKYLLAMVI AYFSRAGFPS
   241  WQYQRIHFFL ALYLANDMEE DDEDSKQNIF HFLYRKNRSR IPLLRKPWFQ LGHSMNPRAR
   301  KNRSRIPLLR KRRFQLYRST NPRARKNRSR IPLLRKRRFQ LYRSMNSRAR KNRSQIVLFQ
   361  KRRFHFFCSM SCRAWVSPEE LEEIQAYDPE HWVWARDRAH LS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPDYE2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
4.5 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.5 nTPM
  • skeletal muscle: 2.9 nTPM
  • small intestine: 1.6 nTPM
  • spleen: 1.3 nTPM
  • pancreas: 1.1 nTPM
  • skin: 0.8 nTPM

Single-cell type

  • cardiomyocytes: 17 nCPM
  • myonuclei: 11 nCPM
  • epicardial cells: 6.8 nCPM
  • adipocytes: 5.5 nCPM
  • cholangiocytes: 5.3 nCPM
  • paneth cells: 3.9 nCPM

Immune cell

  • naive B-cell: 1.6 nTPM
  • neutrophil: 1.5 nTPM
  • basophil: 1.4 nTPM
  • gdT-cell: 1.1 nTPM
  • non-classical monocyte: 1 nTPM
  • plasmacytoid DC: 1 nTPM

Brain region

  • medulla oblongata: 23 nTPM
  • cerebral cortex: 21 nTPM
  • pons: 20 nTPM
  • basal ganglia: 20 nTPM
  • thalamus: 19 nTPM
  • amygdala: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.76
gnomAD pLI
0.38
gnomAD missense Z
0.29

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPDYE2B as an antibody target. Whether an autoantibody or antibody against SPDYE2B could matter depends on whether native SPDYE2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPDYE2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPDYE2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPDYE2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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